Mapping the output of the global literature on the links between gut microbiota and COVID-19

Abstract

Abstract Background The term “human microbiota” refers to populations of microorganisms that live harmoniously in co-existence with humans. They contribute significantly to the host's immunological response when confronted with a respiratory viral infection. However, little is known about the relationship between the human microbiome and COVID-19. Therefore, our objective is to perform a bibliometric analysis to explore the overall structure and hotspots of research activity on the links between microbiota and COVID-19 at the global level. Methods The research literature on the microbiota and COVID-19 published between 2020 and 2022 was obtained from the Scopus database. Bibliometric analysis and network visualization were performed with VOSviewer. Results Of the 701 publications selected, the USA contributed the most (n = 157, 22.40%), followed by China (n = 118, 16.83%) and Italy (n = 82, 11.70%). Hotspots in this field were “COVID-19 is associated with an altered upper respiratory tract microbiome,” “the effect of antibiotics on the gut microbiome,” as well as “patient nutrition and probiotic therapy in COVID-19.” Conclusions The links between microbiota and COVID-19 remain an urgent concern at present, and the use of probiotics or/and antibiotics during the pandemic needs to be further improved. This landscape analysis of the links between the microbiota and COVID-19 will provide a basis for future research.

Keywords

• COVID-19
• Microbiota
• Microbiome
• Bibliometric