Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway

• Benjamin J. R. Moore,
• Barira Islam,
• Sean Ward,
• Olivia Jackson,
• Rebecca Armitage,
• Jack Blackburn,
• Shozeb Haider,
• Patrick C. McHugh

Affiliations

Benjamin J. R. Moore

†Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, U.K.

Barira Islam

†Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, U.K.

Sean Ward

§Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, University of Huddersfield, Huddersfield, U.K.

Olivia Jackson

§Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, University of Huddersfield, Huddersfield, U.K.

Rebecca Armitage

§Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, University of Huddersfield, Huddersfield, U.K.

Jack Blackburn

∥Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, U.K.

Shozeb Haider

UCL School of Pharmacy, London, U.K.

Patrick C. McHugh

†Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, U.K.