Increased risk of platelet thrombosis stimulated by hypomagnesiemia in acute myocardial infarction

Abstract

A randomized pilot study was performed in coronary heart disease (CHD) patients (ejection fraction, EF, close to 40%; diastolic dysfunction) after primary anterior-septal myocardial infarction (MI), complicated with acute heart failure of Killip functional class II-III, Stage II-III arterial hypertension, and platelet magnesium level <1,2 mkmol/mg of protein. Magnesium deficit in plasma, even without severe hypomagnesimia in serum, impaired endothelial secretion of plasminogen activators, and reduced blood fibrinolytic activity, combined with enhanced platelet secretion of serotonin - inflammatory marker and powerful vasoconstrictor. levels of plasma magnesium and fibrinogen directly correlated ([MgJ = 0,37[fibrinogen] + 0,38; r = 0,67, p<0,02). It could be concluded that severe arterial hypertension combined with magnesium deficit play an important role in platelet hemostasis disturbances and high fibrinogen level resistance towards standard MI treatment.

Keywords

• platelets
• plasminogen activator
• magnesium
• acute myocardial infarction
• arterial hypertension