Nature Communications (Jan 2021)

Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

  • Teng Gao,
  • Ryan Ptashkin,
  • Kelly L. Bolton,
  • Maria Sirenko,
  • Christopher Fong,
  • Barbara Spitzer,
  • Kamal Menghrajani,
  • Juan E. Arango Ossa,
  • Yangyu Zhou,
  • Elsa Bernard,
  • Max Levine,
  • Juan S. Medina Martinez,
  • Yanming Zhang,
  • Sebastià Franch-Expósito,
  • Minal Patel,
  • Lior Z. Braunstein,
  • Daniel Kelly,
  • Mariko Yabe,
  • Ryma Benayed,
  • Nicole M. Caltabellotta,
  • John Philip,
  • Ederlinda Paraiso,
  • Simon Mantha,
  • David B. Solit,
  • Luis A. Diaz,
  • Michael F. Berger,
  • Virginia Klimek,
  • Ross L. Levine,
  • Ahmet Zehir,
  • Sean M. Devlin,
  • Elli Papaemmanuil

DOI
https://doi.org/10.1038/s41467-020-20565-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Patients with solid cancers have high rates of clonal haematopoiesis associated with increased risk of secondary leukemias. Here, by using peripheral blood sequencing data from patients with solid non-hematologic cancer, the authors profile the landscape of mosaic chromosomal alterations and gene mutations, defining patients at high risk of leukemia progression.