European Journal of Hybrid Imaging (Jan 2023)

Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies

  • Saifeddine Melki,
  • Thomas Moulinet,
  • Antoine Verger,
  • Pierre-Yves Marie,
  • Laetitia Imbert,
  • Achraf Bahloul

DOI
https://doi.org/10.1186/s41824-022-00160-3
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 4

Abstract

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Abstract Erdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. 18F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective monitoring of the ECD-related bone metabolism abnormalities under treatment was obtained with the standardized uptake value-based information provided by fast whole-body [Tc-99 m]-HDP bone tomoscintigraphies (QWBT) recorded with a high-sensitivity CZT-camera/computed tomography (CT) hybrid system.

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