Universal chimeric antigen receptor T cell therapy — The future of cell therapy: A review providing clinical evidence

Abstract

Autologous CAR-T therapy has shown promising outcomes in the treatment of tumors, particularly hematological malignancies over the past years. However, the application of autologous CAR-T therapy is limited, due to undesirable patient and/or peripheral blood characteristics, the high cost and long time period of manufacturing, and other challenges. Universal CAR-T therapy could overcome major limitations of autologous CAR-T therapy. In this review, we described the research and development status of universal CAR-T therapy for hematological malignancies. In addition, we also summarized the challenges had been encountered and the current solutions.

Keywords

• Universal chimeric antigen receptor T cell therapy
• Allogeneic CAR-T
• Hematological malignancies
• B-ALL
• Immunotherapy