Nature Communications (Sep 2020)
Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity
- J. G. Coen van Hasselt,
- Rayees Rahman,
- Jens Hansen,
- Alan Stern,
- Jaehee V. Shim,
- Yuguang Xiong,
- Amanda Pickard,
- Gomathi Jayaraman,
- Bin Hu,
- Milind Mahajan,
- James M. Gallo,
- Joseph Goldfarb,
- Eric A. Sobie,
- Marc R. Birtwistle,
- Avner Schlessinger,
- Evren U. Azeloglu,
- Ravi Iyengar
Affiliations
- J. G. Coen van Hasselt
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Rayees Rahman
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Jens Hansen
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Alan Stern
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Jaehee V. Shim
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Yuguang Xiong
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Amanda Pickard
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Gomathi Jayaraman
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Bin Hu
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Milind Mahajan
- Department of Genetics and Genomic Sciences, and Icahn Institute for Genomic Sciences and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- James M. Gallo
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Joseph Goldfarb
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Eric A. Sobie
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Marc R. Birtwistle
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Avner Schlessinger
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Evren U. Azeloglu
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- Ravi Iyengar
- Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-020-18396-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug structural signatures to determine an integrated predictive signature of cardiotoxicity.
