Nature Communications (Jun 2020)
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
- Jen-Wei Huang,
- Ananya Acharya,
- Angelo Taglialatela,
- Tarun S. Nambiar,
- Raquel Cuella-Martin,
- Giuseppe Leuzzi,
- Samuel B. Hayward,
- Sarah A. Joseph,
- Gregory J. Brunette,
- Roopesh Anand,
- Rajesh K. Soni,
- Nathan L. Clark,
- Kara A. Bernstein,
- Petr Cejka,
- Alberto Ciccia
Affiliations
- Jen-Wei Huang
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Ananya Acharya
- Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana
- Angelo Taglialatela
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Tarun S. Nambiar
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Raquel Cuella-Martin
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Giuseppe Leuzzi
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Samuel B. Hayward
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Sarah A. Joseph
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Gregory J. Brunette
- Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
- Roopesh Anand
- Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana
- Rajesh K. Soni
- Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Nathan L. Clark
- Department of Human Genetics, University of Utah
- Kara A. Bernstein
- Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
- Petr Cejka
- Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana
- Alberto Ciccia
- Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-16718-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Homologous recombination (HR) is an essential DNA repair pathway for genomic stability. Here the authors show that C17orf53/MCM8IP, an OB-fold containing protein, promotes HR through direct binding and activation of the MCM8-9 helicase complex.
