Oral manifestations in neurofibromatosis type I: A case report

Abstract

Neurofibroma is a benign peripheral nerve sheath tumor, which is one of the most frequent tumors of neural origin. The diagnosis of type 1 neurofibromatosis (NF-I) can be made if there is presence of a neurofibroma. Neurofibromatosis type 1 occurs due to an alteration in the long arm of chromosome 17 and is an autosomal dominant inherited disease. There is no family history of the disease in about 50% of the NF-I patients. NF-I is characterized by the presence of skin lesions (café-au-lait spots and neurofibromas), bone malformations, and central nervous system tumors. A series of clinical criteria decide the diagnosis of NF-I. This article reports a case of NF-I in a 61-year-old male patient with classical features.

Keywords

• Café-au-lait spots
• pedunculated swellings
• neurofibroma