Frontiers in Neuroscience (Mar 2019)
Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
- Ole Kristian Drange,
- Ole Kristian Drange,
- Olav Bjerkehagen Smeland,
- Olav Bjerkehagen Smeland,
- Alexey A. Shadrin,
- Per Ivar Finseth,
- Aree Witoelar,
- Aree Witoelar,
- Oleksandr Frei,
- Psychiatric Genomics Consortium Bipolar Disorder Working Group,
- Yunpeng Wang,
- Yunpeng Wang,
- Sahar Hassani,
- Sahar Hassani,
- Srdjan Djurovic,
- Srdjan Djurovic,
- Anders M. Dale,
- Anders M. Dale,
- Anders M. Dale,
- Ole A. Andreassen,
- Ole A. Andreassen,
- Eli A Stahl,
- Eli A Stahl,
- Eli A Stahl,
- Eli A Stahl,
- Gerome Breen,
- Gerome Breen,
- Gerome Breen,
- Andreas J Forstner,
- Andreas J Forstner,
- Andreas J Forstner,
- Andreas J Forstner,
- Andreas J Forstner,
- Andreas J Forstner,
- Andrew McQuillin,
- Andrew McQuillin,
- Stephan Ripke,
- Stephan Ripke,
- Stephan Ripke,
- Stephan Ripke,
- Vassily Trubetskoy,
- Manuel Mattheisen,
- Manuel Mattheisen,
- Manuel Mattheisen,
- Manuel Mattheisen,
- Manuel Mattheisen,
- Yunpeng Wang,
- Yunpeng Wang,
- Jonathan R I Coleman,
- Jonathan R I Coleman,
- Heìleìna A Gaspar,
- Heìleìna A Gaspar,
- Christiaan A de Leeuw,
- Stacy Steinberg,
- Jennifer M Whitehead Pavlides,
- Maciej Trzaskowski,
- Tune H Pers,
- Tune H Pers,
- Peter A Holmans,
- Liam Abbott,
- Esben Agerbo,
- Esben Agerbo,
- Esben Agerbo,
- Huda Akil,
- Diego Albani,
- Ney Alliey-Rodriguez,
- Thomas D Als,
- Thomas D Als,
- Thomas D Als,
- Adebayo Anjorin,
- Verneri Antilla,
- Swapnil Awasthi,
- Judith A Badner,
- Marie Bækvad-Hansen,
- Marie Bækvad-Hansen,
- Jack D Barchas,
- Nicholas Bass,
- Michael Bauer,
- Richard Belliveau,
- Sarah E Bergen,
- Carsten Bøcker Pedersen,
- Carsten Bøcker Pedersen,
- Carsten Bøcker Pedersen,
- Erlend Bøen,
- Marco Boks,
- James Boocock,
- Monika Budde,
- William Bunney,
- Margit Burmeister,
- Jonas Bybjerg-Grauholm,
- Jonas Bybjerg-Grauholm,
- William Byerley,
- Miquel Casas,
- Miquel Casas,
- Miquel Casas,
- Miquel Casas,
- Felecia Cerrato,
- Pablo Cervantes,
- Kimberly Chambert,
- Alexander W Charney,
- Danfeng Chen,
- Claire Churchhouse,
- Claire Churchhouse,
- Toni-Kim Clarke,
- William Coryell,
- David W Craig,
- Cristiana Cruceanu,
- Cristiana Cruceanu,
- David Curtis,
- David Curtis,
- Piotr M Czerski,
- Anders M Dale,
- Anders M Dale,
- Anders M Dale,
- Anders M Dale,
- Simone de Jong,
- Simone de Jong,
- Franziska Degenhardt,
- Franziska Degenhardt,
- Jurgen Del-Favero,
- J Raymond DePaulo,
- Srdjan Djurovic,
- Srdjan Djurovic,
- Amanda L Dobbyn,
- Amanda L Dobbyn,
- Ashley Dumont,
- Torbjørn Elvsåshagen,
- Torbjørn Elvsåshagen,
- Valentina Escott-Price,
- Chun Chieh Fan,
- Sascha B Fischer,
- Sascha B Fischer,
- Matthew Flickinger,
- Tatiana M Foroud,
- Liz Forty,
- Josef Frank,
- Christine Fraser,
- Nelson B Freimer,
- Louise Friseìn,
- Louise Friseìn,
- Louise Friseìn,
- Katrin Gade,
- Katrin Gade,
- Diane Gage,
- Julie Garnham,
- Claudia Giambartolomei,
- Marianne Giørtz Pedersen,
- Marianne Giørtz Pedersen,
- Marianne Giørtz Pedersen,
- Jaqueline Goldstein,
- Scott D Gordon,
- Katherine Gordon-Smith,
- Elaine K Green,
- Melissa J Green,
- Tiffany A Greenwood,
- Jakob Grove,
- Jakob Grove,
- Jakob Grove,
- Jakob Grove,
- Weihua Guan,
- Joseì Guzman Parra,
- Marian L Hamshere,
- Martin Hautzinger,
- Urs Heilbronner,
- Stefan Herms,
- Stefan Herms,
- Stefan Herms,
- Stefan Herms,
- Maria Hipolito,
- Per Hoffmann,
- Per Hoffmann,
- Per Hoffmann,
- Per Hoffmann,
- Dominic Holland,
- Dominic Holland,
- Laura Huckins,
- Laura Huckins,
- Steìphane Jamain,
- Steìphane Jamain,
- Jessica S Johnson,
- Jessica S Johnson,
- Anders Jureìus,
- Radhika Kandaswamy,
- Robert Karlsson,
- James L Kennedy,
- James L Kennedy,
- James L Kennedy,
- James L Kennedy,
- Sarah Kittel-Schneider,
- Sarah V Knott,
- James A Knowles,
- James A Knowles,
- Manolis Kogevinas,
- Anna C Koller,
- Anna C Koller,
- Ralph Kupka,
- Ralph Kupka,
- Ralph Kupka,
- Catharina Lavebratt,
- Jacob Lawrence,
- William B Lawson,
- Markus Leber,
- Phil H Lee,
- Phil H Lee,
- Phil H Lee,
- Shawn E Levy,
- Jun Z Li,
- Chunyu Liu,
- Susanne Lucae,
- Anna Maaser,
- Anna Maaser,
- Donald J MacIntyre,
- Donald J MacIntyre,
- Pamela B Mahon,
- Pamela B Mahon,
- Wolfgang Maier,
- Lina Martinsson,
- Steve McCarroll,
- Steve McCarroll,
- Peter McGuffin,
- Melvin G McInnis,
- James D McKay,
- Helena Medeiros,
- Sarah E Medland,
- Fan Meng,
- Fan Meng,
- Lili Milani,
- Grant W Montgomery,
- Derek W Morris,
- Derek W Morris,
- Thomas W Mühleisen,
- Thomas W Mühleisen,
- Niamh Mullins,
- Hoang Nguyen,
- Hoang Nguyen,
- Caroline M Nievergelt,
- Caroline M Nievergelt,
- Annelie Nordin Adolfsson,
- Evaristus A Nwulia,
- Claire O’Donovan,
- Loes M Olde Loohuis,
- Anil P S Ori,
- Lilijana Oruc,
- Urban Ösby,
- Roy H Perlis,
- Roy H Perlis,
- Amy Perry,
- Andrea Pfennig,
- James B Potash,
- Shaun M Purcell,
- Shaun M Purcell,
- Eline J Regeer,
- Andreas Reif,
- Ceìline S Reinbold,
- Ceìline S Reinbold,
- John P Rice,
- Fabio Rivas,
- Margarita Rivera,
- Margarita Rivera,
- Panos Roussos,
- Panos Roussos,
- Panos Roussos,
- Douglas M Ruderfer,
- Euijung Ryu,
- Cristina Saìnchez-Mora,
- Cristina Saìnchez-Mora,
- Cristina Saìnchez-Mora,
- Alan F Schatzberg,
- William A Scheftner,
- Nicholas J Schork,
- Cynthia Shannon Weickert,
- Cynthia Shannon Weickert,
- Tatyana Shehktman,
- Paul D Shilling,
- Engilbert Sigurdsson,
- Claire Slaney,
- Olav B Smeland,
- Olav B Smeland,
- Olav B Smeland,
- Janet L Sobell,
- Christine Søholm Hansen,
- Christine Søholm Hansen,
- Anne T Spijker,
- David St Clair,
- Michael Steffens,
- John S Strauss,
- John S Strauss,
- Fabian Streit,
- Jana Strohmaier,
- Szabolcs Szelinger,
- Robert C Thompson,
- Thorgeir E Thorgeirsson,
- Jens Treutlein,
- Helmut Vedder,
- Weiqing Wang,
- Weiqing Wang,
- Stanley J Watson,
- Thomas W Weickert,
- Thomas W Weickert,
- Stephanie H Witt,
- Simon Xi,
- Wei Xu,
- Wei Xu,
- Allan H Young,
- Peter Zandi,
- Peng Zhang,
- Sebastian Zollner,
- Rolf Adolfsson,
- Ingrid Agartz,
- Ingrid Agartz,
- Ingrid Agartz,
- Martin Alda,
- Martin Alda,
- Lena Backlund,
- Bernhard T Baune,
- Frank Bellivier,
- Frank Bellivier,
- Frank Bellivier,
- Frank Bellivier,
- Wade H Berrettini,
- Joanna M Biernacka,
- Douglas H R Blackwood,
- Michael Boehnke,
- Anders D Børglum,
- Anders D Børglum,
- Anders D Børglum,
- Aiden Corvin,
- Nicholas Craddock,
- Mark J Daly,
- Mark J Daly,
- Udo Dannlowski,
- ToÞnu Esko,
- ToÞnu Esko,
- ToÞnu Esko,
- ToÞnu Esko,
- Bruno Etain,
- Bruno Etain,
- Bruno Etain,
- Bruno Etain,
- Mark Frye,
- Janice M Fullerton,
- Janice M Fullerton,
- Elliot S Gershon,
- Elliot S Gershon,
- Michael Gill,
- Fernando Goes,
- Maria Grigoroiu-Serbanescu,
- Joanna Hauser,
- David M Hougaard,
- David M Hougaard,
- Christina M Hultman,
- Ian Jones,
- Lisa A Jones,
- Reneì S Kahn,
- Reneì S Kahn,
- George Kirov,
- Mikael Landeìn,
- Mikael Landeìn,
- Marion Leboyer,
- Marion Leboyer,
- Marion Leboyer,
- Cathryn M Lewis,
- Cathryn M Lewis,
- Cathryn M Lewis,
- Qingqin S Li,
- Jolanta Lissowska,
- Nicholas G Martin,
- Nicholas G Martin,
- Fermin Mayoral,
- Susan L McElroy,
- Andrew M McIntosh,
- Andrew M McIntosh,
- Francis J McMahon,
- Ingrid Melle,
- Ingrid Melle,
- Andres Metspalu,
- Andres Metspalu,
- Philip B Mitchell,
- Gunnar Morken,
- Gunnar Morken,
- Ole Mors,
- Ole Mors,
- Preben Bo Mortensen,
- Preben Bo Mortensen,
- Preben Bo Mortensen,
- Preben Bo Mortensen,
- Bertram Müller-Myhsok,
- Bertram Müller-Myhsok,
- Bertram Müller-Myhsok,
- Richard M Myers,
- Benjamin M Neale,
- Benjamin M Neale,
- Benjamin M Neale,
- Vishwajit Nimgaonkar,
- Merete Nordentoft,
- Merete Nordentoft,
- Markus M Nöthen,
- Markus M Nöthen,
- Michael C O’Donovan,
- Ketil J Oedegaard,
- Ketil J Oedegaard,
- Michael J Owen,
- Sara A Paciga,
- Carlos Pato,
- Carlos Pato,
- Michele T Pato,
- Danielle Posthuma,
- Danielle Posthuma,
- Josep Antoni Ramos-Quiroga,
- Josep Antoni Ramos-Quiroga,
- Josep Antoni Ramos-Quiroga,
- Josep Antoni Ramos-Quiroga,
- Marta Ribaseìs,
- Marta Ribaseìs,
- Marta Ribaseìs,
- Marcella Rietschel,
- Guy A Rouleau,
- Guy A Rouleau,
- Martin Schalling,
- Peter R Schofield,
- Peter R Schofield,
- Thomas G Schulze,
- Thomas G Schulze,
- Thomas G Schulze,
- Thomas G Schulze,
- Thomas G Schulze,
- Alessandro Serretti,
- Jordan W Smoller,
- Jordan W Smoller,
- Jordan W Smoller,
- Hreinn Stefansson,
- Kari Stefansson,
- Kari Stefansson,
- Eystein Stordal,
- Eystein Stordal,
- Patrick F Sullivan,
- Patrick F Sullivan,
- Patrick F Sullivan,
- Gustavo Turecki,
- Arne E Vaaler,
- Eduard Vieta,
- John B Vincent,
- Thomas Werge,
- Thomas Werge,
- Thomas Werge,
- John I Nurnberger,
- Naomi R Wray,
- Naomi R Wray,
- Arianna Di Florio,
- Arianna Di Florio,
- Howard J Edenberg,
- Sven Cichon,
- Sven Cichon,
- Sven Cichon,
- Sven Cichon,
- Roel A Ophoff,
- Roel A Ophoff,
- Roel A Ophoff,
- Laura J Scott,
- Ole A Andreassen,
- Ole A Andreassen,
- John Kelsoe,
- John Kelsoe,
- Pamela Sklar,
- Pamela Sklar,
- Pamela Sklar,
- Pamela Sklar
Affiliations
- Ole Kristian Drange
- Department of Research and Development, Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway
- Ole Kristian Drange
- Department of Østmarka, Division of Mental Health Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
- Olav Bjerkehagen Smeland
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Olav Bjerkehagen Smeland
- Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
- Alexey A. Shadrin
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Per Ivar Finseth
- Department of Brøset, Division of Mental Health Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
- Aree Witoelar
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Aree Witoelar
- Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
- Oleksandr Frei
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Psychiatric Genomics Consortium Bipolar Disorder Working Group
- Yunpeng Wang
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Yunpeng Wang
- Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
- Sahar Hassani
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Sahar Hassani
- Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
- Srdjan Djurovic
- Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
- Srdjan Djurovic
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway
- Anders M. Dale
- Center for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, CA, United States
- Anders M. Dale
- Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States
- Anders M. Dale
- 0Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
- Ole A. Andreassen
- Norwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- Ole A. Andreassen
- Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
- Eli A Stahl
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Eli A Stahl
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Eli A Stahl
- Medical and Population Genetics, Broad Institute, Cambridge, MA, US
- Eli A Stahl
- Equal contribution
- Gerome Breen
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Gerome Breen
- NIHR BRC for Mental Health, King’s College London, London, GB
- Gerome Breen
- Equal contribution
- Andreas J Forstner
- Department of Biomedicine, University of Basel, Basel, CH
- Andreas J Forstner
- Department of Psychiatry (UPK), University of Basel, Basel, CH
- Andreas J Forstner
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Andreas J Forstner
- Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- Andreas J Forstner
- 0 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, CH
- Andreas J Forstner
- Equal contribution
- Andrew McQuillin
- 1 Division of Psychiatry, University College London, London, GB
- Andrew McQuillin
- Equal contribution
- Stephan Ripke
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Stephan Ripke
- 3 Department of Psychiatry and Psychotherapy, Chariteì - Universitätsmedizin, Berlin, DE
- Stephan Ripke
- 4 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- Stephan Ripke
- Equal contribution
- Vassily Trubetskoy
- 3 Department of Psychiatry and Psychotherapy, Chariteì - Universitätsmedizin, Berlin, DE
- Manuel Mattheisen
- 5 iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, DK
- Manuel Mattheisen
- 6 Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK
- Manuel Mattheisen
- 7 Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, SE
- Manuel Mattheisen
- 8 Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, DE
- Manuel Mattheisen
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Yunpeng Wang
- 0 Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, DK
- Yunpeng Wang
- 1 Institute of Clinical Medicine, University of Oslo, Oslo, NO
- Jonathan R I Coleman
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Jonathan R I Coleman
- NIHR BRC for Mental Health, King’s College London, London, GB
- Heìleìna A Gaspar
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Heìleìna A Gaspar
- NIHR BRC for Mental Health, King’s College London, London, GB
- Christiaan A de Leeuw
- 2 Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, NL
- Stacy Steinberg
- 3 deCODE Genetics / Amgen, Reykjavik, IS
- Jennifer M Whitehead Pavlides
- 4 Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU
- Maciej Trzaskowski
- 5 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Tune H Pers
- Medical and Population Genetics, Broad Institute, Cambridge, MA, US
- Tune H Pers
- 6 Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, US
- Peter A Holmans
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Liam Abbott
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Esben Agerbo
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Esben Agerbo
- 8 National Centre for Register-Based Research, Aarhus University, Aarhus, DK
- Esben Agerbo
- 9 Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK
- Huda Akil
- 0 Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, US
- Diego Albani
- 1 NEUROSCIENCE, Istituto Di Ricerche Farmacologiche Mario Negri, Milano, IT
- Ney Alliey-Rodriguez
- 2 Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, US
- Thomas D Als
- 5 iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, DK
- Thomas D Als
- 6 Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK
- Thomas D Als
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Adebayo Anjorin
- 3 Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, GB
- Verneri Antilla
- 4 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- Swapnil Awasthi
- 3 Department of Psychiatry and Psychotherapy, Chariteì - Universitätsmedizin, Berlin, DE
- Judith A Badner
- 4 Psychiatry, Rush University Medical Center, Chicago, IL, US
- Marie Bækvad-Hansen
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Marie Bækvad-Hansen
- 5 Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- Jack D Barchas
- 6 Department of Psychiatry, Weill Cornell Medical College, New York, NY, US
- Nicholas Bass
- 1 Division of Psychiatry, University College London, London, GB
- Michael Bauer
- 7 Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, DE
- Richard Belliveau
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Sarah E Bergen
- 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Carsten Bøcker Pedersen
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Carsten Bøcker Pedersen
- 8 National Centre for Register-Based Research, Aarhus University, Aarhus, DK
- Carsten Bøcker Pedersen
- 9 Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK
- Erlend Bøen
- 9 Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, NO
- Marco Boks
- 0 Psychiatry, UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, NL
- James Boocock
- 1 Human Genetics, University of California Los Angeles, Los Angeles, CA, US
- Monika Budde
- 2 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, DE
- William Bunney
- 3 Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, US
- Margit Burmeister
- 4 Molecular & Behavioral Neuroscience Institute and Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, US
- Jonas Bybjerg-Grauholm
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Jonas Bybjerg-Grauholm
- 5 Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- William Byerley
- 5 Psychiatry, University of California San Francisco, San Francisco, CA, US
- Miquel Casas
- 6 Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, ES
- Miquel Casas
- 7 Department of Psychiatry, Hospital Universitari Vall d ìHebron, Barcelona, ES
- Miquel Casas
- 8 Department of Psychiatry and Forensic Medicine, Universitat Autoìnoma de Barcelona, Barcelona, ES
- Miquel Casas
- 9 Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d ìHebron Research Institut (VHIR), Universitat Autoìnoma de Barcelona, Barcelona, ES
- Felecia Cerrato
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Pablo Cervantes
- 0 Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, QC, CA
- Kimberly Chambert
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Alexander W Charney
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Danfeng Chen
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Claire Churchhouse
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Claire Churchhouse
- 4 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- Toni-Kim Clarke
- 1 Division of Psychiatry, University of Edinburgh, Edinburgh, GB
- William Coryell
- 2 University of Iowa Hospitals and Clinics, Iowa City, IA, US
- David W Craig
- 3 Translational Genomics, USC, Phoenix, AZ, US
- Cristiana Cruceanu
- 0 Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, QC, CA
- Cristiana Cruceanu
- 4 Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, DE
- David Curtis
- 5 Centre for Psychiatry, Queen Mary University of London, London, GB
- David Curtis
- 6 UCL Genetics Institute, University College London, London, GB
- Piotr M Czerski
- 7 Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, PL
- Anders M Dale
- 8 Department of Neurosciences, University of California San Diego, La Jolla, CA, US
- Anders M Dale
- 9 Department of Radiology, University of California San Diego, La Jolla, CA, US
- Anders M Dale
- 0 Department of Psychiatry, University of California San Diego, La Jolla, CA, US
- Anders M Dale
- 1 Department of Cognitive Science, University of California San Diego, La Jolla, CA, US
- Simone de Jong
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Simone de Jong
- NIHR BRC for Mental Health, King’s College London, London, GB
- Franziska Degenhardt
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Franziska Degenhardt
- Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- Jurgen Del-Favero
- 2 Applied Molecular Genomics Unit, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium
- J Raymond DePaulo
- 3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, US
- Srdjan Djurovic
- 4 Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, NO
- Srdjan Djurovic
- 5 NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, NO
- Amanda L Dobbyn
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Amanda L Dobbyn
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Ashley Dumont
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Torbjørn Elvsåshagen
- 6 Department of Neurology, Oslo University Hospital, Oslo, NO
- Torbjørn Elvsåshagen
- 7 NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, NO
- Valentina Escott-Price
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Chun Chieh Fan
- 1 Department of Cognitive Science, University of California San Diego, La Jolla, CA, US
- Sascha B Fischer
- Department of Biomedicine, University of Basel, Basel, CH
- Sascha B Fischer
- 0 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, CH
- Matthew Flickinger
- 8 Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, US
- Tatiana M Foroud
- 9 Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, US
- Liz Forty
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Josef Frank
- 0 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- Christine Fraser
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Nelson B Freimer
- 1 Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, US
- Louise Friseìn
- 2 Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SE
- Louise Friseìn
- 3 Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SE
- Louise Friseìn
- 4 Child and Adolescent Psychiatry Research Center, Stockholm, SE
- Katrin Gade
- 2 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, DE
- Katrin Gade
- 5 Department of Psychiatry and Psychotherapy, University Medical Center GÖttingen, GÖttingen, DE
- Diane Gage
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Julie Garnham
- 6 Department of Psychiatry, Dalhousie University, Halifax, NS, CA
- Claudia Giambartolomei
- 1 Human Genetics, University of California Los Angeles, Los Angeles, CA, US
- Marianne Giørtz Pedersen
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Marianne Giørtz Pedersen
- 8 National Centre for Register-Based Research, Aarhus University, Aarhus, DK
- Marianne Giørtz Pedersen
- 9 Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK
- Jaqueline Goldstein
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Scott D Gordon
- 7 Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Katherine Gordon-Smith
- 8 Department of Psychological Medicine, University of Worcester, Worcester, GB
- Elaine K Green
- 9 School of Biomedical and Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, GB
- Melissa J Green
- 0 School of Psychiatry, University of New South Wales, Sydney, NSW, AU
- Tiffany A Greenwood
- 0 Department of Psychiatry, University of California San Diego, La Jolla, CA, US
- Jakob Grove
- 5 iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, DK
- Jakob Grove
- 6 Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK
- Jakob Grove
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Jakob Grove
- 1 Bioinformatics Research Centre, Aarhus University, Aarhus, DK
- Weihua Guan
- 2 Biostatistics, University of Minnesota System, Minneapolis, MN, US
- Joseì Guzman Parra
- 3 Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Maìlaga, ES
- Marian L Hamshere
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Martin Hautzinger
- 4 Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, DE
- Urs Heilbronner
- 2 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, DE
- Stefan Herms
- Department of Biomedicine, University of Basel, Basel, CH
- Stefan Herms
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Stefan Herms
- Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- Stefan Herms
- 0 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, CH
- Maria Hipolito
- 5 Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, US
- Per Hoffmann
- Department of Biomedicine, University of Basel, Basel, CH
- Per Hoffmann
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Per Hoffmann
- Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- Per Hoffmann
- 0 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, CH
- Dominic Holland
- 8 Department of Neurosciences, University of California San Diego, La Jolla, CA, US
- Dominic Holland
- 6 Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, US
- Laura Huckins
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Laura Huckins
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Steìphane Jamain
- 7 Psychiatrie Translationnelle, Inserm U955, Creìteil, FR
- Steìphane Jamain
- 8 Faculteì de Meìdecine, Universiteì Paris Est, Creìteil, FR
- Jessica S Johnson
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Jessica S Johnson
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Anders Jureìus
- 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Radhika Kandaswamy
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Robert Karlsson
- 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- James L Kennedy
- 9 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, CA
- James L Kennedy
- 0 Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, CA
- James L Kennedy
- 1 Department of Psychiatry, University of Toronto, Toronto, ON, CA
- James L Kennedy
- 2 Institute of Medical Sciences, University of Toronto, Toronto, ON, CA
- Sarah Kittel-Schneider
- 3 Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, DE
- Sarah V Knott
- 8 Department of Psychological Medicine, University of Worcester, Worcester, GB
- James A Knowles
- 4 Cell Biology, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- James A Knowles
- 5 Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- Manolis Kogevinas
- 6 Center for Research in Environmental Epidemiology (CREAL), Barcelona, ES
- Anna C Koller
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Anna C Koller
- Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- Ralph Kupka
- 7 Psychiatry, Altrecht, Utrecht, NL
- Ralph Kupka
- 8 Psychiatry, GGZ inGeest, Amsterdam, NL
- Ralph Kupka
- 9 Psychiatry, VU medisch centrum, Amsterdam, NL
- Catharina Lavebratt
- 2 Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SE
- Jacob Lawrence
- 00 Psychiatry, North East London NHS Foundation Trust, Ilford, GB
- William B Lawson
- 5 Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, US
- Markus Leber
- 01 Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, DE
- Phil H Lee
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Phil H Lee
- 4 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- Phil H Lee
- 02 Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- Shawn E Levy
- 03 HudsonAlpha Institute for Biotechnology, Huntsville, AL, US
- Jun Z Li
- 04 Department of Human Genetics, University of Michigan, Ann Arbor, MI, US
- Chunyu Liu
- 05 Psychiatry, University of Illinois at Chicago College of Medicine, Chicago, IL, US
- Susanne Lucae
- 06 Max Planck Institute of Psychiatry, Munich, DE
- Anna Maaser
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Anna Maaser
- Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- Donald J MacIntyre
- 07 Mental Health, NHS 24, Glasgow, GB
- Donald J MacIntyre
- 08 Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, GB
- Pamela B Mahon
- 3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, US
- Pamela B Mahon
- 09 Psychiatry, Brigham and Women’s Hospital, Boston, MA, US
- Wolfgang Maier
- 10 Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, DE
- Lina Martinsson
- 3 Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SE
- Steve McCarroll
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Steve McCarroll
- 11 Department of Genetics, Harvard Medical School, Boston, MA, US
- Peter McGuffin
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Melvin G McInnis
- 12 Department of Psychiatry, University of Michigan, Ann Arbor, MI, US
- James D McKay
- 13 Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, FR
- Helena Medeiros
- 5 Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- Sarah E Medland
- 7 Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Fan Meng
- 0 Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, US
- Fan Meng
- 12 Department of Psychiatry, University of Michigan, Ann Arbor, MI, US
- Lili Milani
- 14 Estonian Genome Center, University of Tartu, Tartu, EE
- Grant W Montgomery
- 5 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Derek W Morris
- 15 Discipline of Biochemistry, Neuroimaging and Cognitive Genomics (NICOG) Centre, National University of Ireland, Galway, Galway, IE
- Derek W Morris
- 16 Neuropsychiatric Genetics Research Group, Dept of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IE
- Thomas W Mühleisen
- Department of Biomedicine, University of Basel, Basel, CH
- Thomas W Mühleisen
- 17 Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, DE
- Niamh Mullins
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Hoang Nguyen
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Hoang Nguyen
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Caroline M Nievergelt
- 0 Department of Psychiatry, University of California San Diego, La Jolla, CA, US
- Caroline M Nievergelt
- 18 Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, US
- Annelie Nordin Adolfsson
- 19 Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, SE
- Evaristus A Nwulia
- 5 Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, US
- Claire O’Donovan
- 6 Department of Psychiatry, Dalhousie University, Halifax, NS, CA
- Loes M Olde Loohuis
- 1 Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, US
- Anil P S Ori
- 1 Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, US
- Lilijana Oruc
- 20 Department of Clinical Psychiatry, Psychiatry Clinic, Clinical Center University of Sarajevo, Sarajevo, BA
- Urban Ösby
- 21 Department of Neurobiology, Care sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SE
- Roy H Perlis
- 22 Psychiatry, Harvard Medical School, Boston, MA, US
- Roy H Perlis
- 23 Division of Clinical Research, Massachusetts General Hospital, Boston, MA, US
- Amy Perry
- 8 Department of Psychological Medicine, University of Worcester, Worcester, GB
- Andrea Pfennig
- 7 Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, DE
- James B Potash
- 3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, US
- Shaun M Purcell
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Shaun M Purcell
- 09 Psychiatry, Brigham and Women’s Hospital, Boston, MA, US
- Eline J Regeer
- 24 Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, NL
- Andreas Reif
- 3 Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, DE
- Ceìline S Reinbold
- Department of Biomedicine, University of Basel, Basel, CH
- Ceìline S Reinbold
- 0 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, CH
- John P Rice
- 25 Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, US
- Fabio Rivas
- 3 Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Maìlaga, ES
- Margarita Rivera
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Margarita Rivera
- 26 Department of Biochemistry and Molecular Biology II, Institute of Neurosciences, Center for Biomedical Research, University of Granada, Granada, ES
- Panos Roussos
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Panos Roussos
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Panos Roussos
- 27 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Douglas M Ruderfer
- 28 Medicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, US
- Euijung Ryu
- 29 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, US
- Cristina Saìnchez-Mora
- 6 Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, ES
- Cristina Saìnchez-Mora
- 7 Department of Psychiatry, Hospital Universitari Vall d ìHebron, Barcelona, ES
- Cristina Saìnchez-Mora
- 9 Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d ìHebron Research Institut (VHIR), Universitat Autoìnoma de Barcelona, Barcelona, ES
- Alan F Schatzberg
- 30 Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, US
- William A Scheftner
- 31 Rush University Medical Center, Chicago, IL, US
- Nicholas J Schork
- 32 Scripps Translational Science Institute, La Jolla, CA, US
- Cynthia Shannon Weickert
- 0 School of Psychiatry, University of New South Wales, Sydney, NSW, AU
- Cynthia Shannon Weickert
- 33 Neuroscience Research Australia, Sydney, NSW, AU
- Tatyana Shehktman
- 0 Department of Psychiatry, University of California San Diego, La Jolla, CA, US
- Paul D Shilling
- 0 Department of Psychiatry, University of California San Diego, La Jolla, CA, US
- Engilbert Sigurdsson
- 34 Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, IS
- Claire Slaney
- 6 Department of Psychiatry, Dalhousie University, Halifax, NS, CA
- Olav B Smeland
- 8 Department of Neurosciences, University of California San Diego, La Jolla, CA, US
- Olav B Smeland
- 35 Div Mental Health and Addiction, Oslo University Hospital, Oslo, NO
- Olav B Smeland
- 36 NORMENT, University of Oslo, Oslo, NO
- Janet L Sobell
- 37 Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, US
- Christine Søholm Hansen
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Christine Søholm Hansen
- 5 Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- Anne T Spijker
- 38 Mood Disorders, PsyQ, Rotterdam, NL
- David St Clair
- 39 Institute for Medical Sciences, University of Aberdeen, Aberdeen, UK
- Michael Steffens
- 40 Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, DE
- John S Strauss
- 1 Department of Psychiatry, University of Toronto, Toronto, ON, CA
- John S Strauss
- 41 Centre for Addiction and Mental Health, Toronto, ON, CA
- Fabian Streit
- 0 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- Jana Strohmaier
- 0 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- Szabolcs Szelinger
- 42 Neurogenomics, TGen, Los Angeles, AZ, US
- Robert C Thompson
- 12 Department of Psychiatry, University of Michigan, Ann Arbor, MI, US
- Thorgeir E Thorgeirsson
- 3 deCODE Genetics / Amgen, Reykjavik, IS
- Jens Treutlein
- 0 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- Helmut Vedder
- 43 Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, DE
- Weiqing Wang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Weiqing Wang
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Stanley J Watson
- 12 Department of Psychiatry, University of Michigan, Ann Arbor, MI, US
- Thomas W Weickert
- 0 School of Psychiatry, University of New South Wales, Sydney, NSW, AU
- Thomas W Weickert
- 33 Neuroscience Research Australia, Sydney, NSW, AU
- Stephanie H Witt
- 0 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- Simon Xi
- 44 Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, US
- Wei Xu
- 45 Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, CA
- Wei Xu
- 46 Dalla Lana School of Public Health, University of Toronto, Toronto, ON, CA
- Allan H Young
- 47 Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, GB
- Peter Zandi
- 48 Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, US
- Peng Zhang
- 49 Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, US
- Sebastian Zollner
- 12 Department of Psychiatry, University of Michigan, Ann Arbor, MI, US
- Rolf Adolfsson
- 19 Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, SE
- Ingrid Agartz
- 7 Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, SE
- Ingrid Agartz
- 9 Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, NO
- Ingrid Agartz
- 50 NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Oslo, NO
- Martin Alda
- 6 Department of Psychiatry, Dalhousie University, Halifax, NS, CA
- Martin Alda
- 51 National Institute of Mental Health, Klecany, CZ
- Lena Backlund
- 3 Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SE
- Bernhard T Baune
- 52 Discipline of Psychiatry, University of Adelaide, Adelaide, SA, AU
- Frank Bellivier
- 53 Department of Psychiatry and Addiction Medicine, Assistance Publique - Ho^pitaux de Paris, Paris, FR
- Frank Bellivier
- 54 Paris Bipolar and TRD Expert Centres, FondaMental Foundation, Paris, FR
- Frank Bellivier
- 55 UMR-S1144 Team 1: Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris, FR
- Frank Bellivier
- 56 Psychiatry, Universiteì Paris Diderot, Paris, FR
- Wade H Berrettini
- 57 Psychiatry, University of Pennsylvania, Philadelphia, PA, US
- Joanna M Biernacka
- 29 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, US
- Douglas H R Blackwood
- 1 Division of Psychiatry, University of Edinburgh, Edinburgh, GB
- Michael Boehnke
- 8 Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, US
- Anders D Børglum
- 5 iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, DK
- Anders D Børglum
- 6 Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK
- Anders D Børglum
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Aiden Corvin
- 16 Neuropsychiatric Genetics Research Group, Dept of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IE
- Nicholas Craddock
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Mark J Daly
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Mark J Daly
- 4 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- Udo Dannlowski
- 58 Department of Psychiatry, University of Münster, Münster, DE
- ToÞnu Esko
- Medical and Population Genetics, Broad Institute, Cambridge, MA, US
- ToÞnu Esko
- 11 Department of Genetics, Harvard Medical School, Boston, MA, US
- ToÞnu Esko
- 14 Estonian Genome Center, University of Tartu, Tartu, EE
- ToÞnu Esko
- 59 Division of Endocrinology, Children’s Hospital Boston, Boston, MA, US
- Bruno Etain
- 53 Department of Psychiatry and Addiction Medicine, Assistance Publique - Ho^pitaux de Paris, Paris, FR
- Bruno Etain
- 55 UMR-S1144 Team 1: Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris, FR
- Bruno Etain
- 56 Psychiatry, Universiteì Paris Diderot, Paris, FR
- Bruno Etain
- 60 Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, London, GB
- Mark Frye
- 61 Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, US
- Janice M Fullerton
- 33 Neuroscience Research Australia, Sydney, NSW, AU
- Janice M Fullerton
- 62 School of Medical Sciences, University of New South Wales, Sydney, NSW, AU
- Elliot S Gershon
- 2 Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, US
- Elliot S Gershon
- 63 Department of Human Genetics, University of Chicago, Chicago, IL, US
- Michael Gill
- 16 Neuropsychiatric Genetics Research Group, Dept of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IE
- Fernando Goes
- 3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, US
- Maria Grigoroiu-Serbanescu
- 64 Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, RO
- Joanna Hauser
- 7 Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, PL
- David M Hougaard
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- David M Hougaard
- 5 Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- Christina M Hultman
- 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Ian Jones
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Lisa A Jones
- 8 Department of Psychological Medicine, University of Worcester, Worcester, GB
- Reneì S Kahn
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Reneì S Kahn
- 0 Psychiatry, UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, NL
- George Kirov
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Mikael Landeìn
- 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Mikael Landeìn
- 65 Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, SE
- Marion Leboyer
- 8 Faculteì de Meìdecine, Universiteì Paris Est, Creìteil, FR
- Marion Leboyer
- 53 Department of Psychiatry and Addiction Medicine, Assistance Publique - Ho^pitaux de Paris, Paris, FR
- Marion Leboyer
- 66 INSERM, Paris, FR
- Cathryn M Lewis
- MRC Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Cathryn M Lewis
- NIHR BRC for Mental Health, King’s College London, London, GB
- Cathryn M Lewis
- 67 Department of Medical & Molecular Genetics, King’s College London, London, GB
- Qingqin S Li
- 68 Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, US
- Jolanta Lissowska
- 69 Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, PL
- Nicholas G Martin
- 7 Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Nicholas G Martin
- 70 School of Psychology, The University of Queensland, Brisbane, QLD, AU
- Fermin Mayoral
- 3 Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Maìlaga, ES
- Susan L McElroy
- 71 Research Institute, Lindner Center of HOPE, Mason, OH, US
- Andrew M McIntosh
- 1 Division of Psychiatry, University of Edinburgh, Edinburgh, GB
- Andrew M McIntosh
- 72 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, GB
- Francis J McMahon
- 73 Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US
- Ingrid Melle
- 74 Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NO
- Ingrid Melle
- 75 Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, NO
- Andres Metspalu
- 14 Estonian Genome Center, University of Tartu, Tartu, EE
- Andres Metspalu
- 76 Institute of Molecular and Cell Biology, University of Tartu, Tartu, EE
- Philip B Mitchell
- 0 School of Psychiatry, University of New South Wales, Sydney, NSW, AU
- Gunnar Morken
- 77 Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology - NTNU, Trondheim, NO
- Gunnar Morken
- 78 Psychiatry, St Olavs University Hospital, Trondheim, NO
- Ole Mors
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Ole Mors
- 79 Psychosis Research Unit, Aarhus University Hospital, Risskov, DK
- Preben Bo Mortensen
- 5 iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, DK
- Preben Bo Mortensen
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Preben Bo Mortensen
- 8 National Centre for Register-Based Research, Aarhus University, Aarhus, DK
- Preben Bo Mortensen
- 9 Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK
- Bertram Müller-Myhsok
- 4 Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, DE
- Bertram Müller-Myhsok
- 80 Munich Cluster for Systems Neurology (SyNergy), Munich, DE
- Bertram Müller-Myhsok
- 81 University of Liverpool, Liverpool, GB
- Richard M Myers
- 03 HudsonAlpha Institute for Biotechnology, Huntsville, AL, US
- Benjamin M Neale
- Medical and Population Genetics, Broad Institute, Cambridge, MA, US
- Benjamin M Neale
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Benjamin M Neale
- 4 Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US
- Vishwajit Nimgaonkar
- 82 Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, US
- Merete Nordentoft
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Merete Nordentoft
- 83 Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, DK
- Markus M Nöthen
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Markus M Nöthen
- Life&Brain Center, Department of Genomics, University of Bonn, Bonn, DE
- Michael C O’Donovan
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Ketil J Oedegaard
- 84 Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, NO
- Ketil J Oedegaard
- 85 Faculty of Medicine and Dentistry, University of Bergen, Bergen, NO
- Michael J Owen
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Sara A Paciga
- 86 Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, US
- Carlos Pato
- 5 Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- Carlos Pato
- 87 College of Medicine Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- Michele T Pato
- 5 Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, US
- Danielle Posthuma
- 2 Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, NL
- Danielle Posthuma
- 88 Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, NL
- Josep Antoni Ramos-Quiroga
- 6 Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, ES
- Josep Antoni Ramos-Quiroga
- 7 Department of Psychiatry, Hospital Universitari Vall d ìHebron, Barcelona, ES
- Josep Antoni Ramos-Quiroga
- 8 Department of Psychiatry and Forensic Medicine, Universitat Autoìnoma de Barcelona, Barcelona, ES
- Josep Antoni Ramos-Quiroga
- 9 Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d ìHebron Research Institut (VHIR), Universitat Autoìnoma de Barcelona, Barcelona, ES
- Marta Ribaseìs
- 6 Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, ES
- Marta Ribaseìs
- 7 Department of Psychiatry, Hospital Universitari Vall d ìHebron, Barcelona, ES
- Marta Ribaseìs
- 9 Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d ìHebron Research Institut (VHIR), Universitat Autoìnoma de Barcelona, Barcelona, ES
- Marcella Rietschel
- 0 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- Guy A Rouleau
- 89 Department of Neurology and Neurosurgery, McGill University, Faculty of Medicine, Montreal, QC, CA
- Guy A Rouleau
- 90 Montreal Neurological Institute and Hospital, Montreal, QC, CA
- Martin Schalling
- 2 Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SE
- Peter R Schofield
- 33 Neuroscience Research Australia, Sydney, NSW, AU
- Peter R Schofield
- 62 School of Medical Sciences, University of New South Wales, Sydney, NSW, AU
- Thomas G Schulze
- 2 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, DE
- Thomas G Schulze
- 3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, US
- Thomas G Schulze
- 0 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, DE
- Thomas G Schulze
- 5 Department of Psychiatry and Psychotherapy, University Medical Center GÖttingen, GÖttingen, DE
- Thomas G Schulze
- 73 Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, US
- Alessandro Serretti
- 91 Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, IT
- Jordan W Smoller
- 2 Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Jordan W Smoller
- 92 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, US
- Jordan W Smoller
- 93 Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, US
- Hreinn Stefansson
- 3 deCODE Genetics / Amgen, Reykjavik, IS
- Kari Stefansson
- 3 deCODE Genetics / Amgen, Reykjavik, IS
- Kari Stefansson
- 94 Faculty of Medicine, University of Iceland, Reykjavik, IS
- Eystein Stordal
- 95 Department of Psychiatry, Hospital Namsos, Namsos, NO
- Eystein Stordal
- 96 Department of Neuroscience, Norges Teknisk Naturvitenskapelige Universitet Fakultet for naturvitenskap og teknologi, Trondheim, NO
- Patrick F Sullivan
- 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Patrick F Sullivan
- 97 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, US
- Patrick F Sullivan
- 98 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, US
- Gustavo Turecki
- 99 Department of Psychiatry, McGill University, Montreal, QC, CA
- Arne E Vaaler
- 00 Dept of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, NO
- Eduard Vieta
- 01 Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, ES
- John B Vincent
- 41 Centre for Addiction and Mental Health, Toronto, ON, CA
- Thomas Werge
- 9 iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Thomas Werge
- 02 Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, DK
- Thomas Werge
- 03 Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK
- John I Nurnberger
- 04 Psychiatry, Indiana University School of Medicine, Indianapolis, IN, US
- Naomi R Wray
- 4 Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU
- Naomi R Wray
- 5 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Arianna Di Florio
- 7 Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, GB
- Arianna Di Florio
- 98 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, US
- Howard J Edenberg
- 05 Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, US
- Sven Cichon
- Department of Biomedicine, University of Basel, Basel, CH
- Sven Cichon
- Institute of Human Genetics, University of Bonn, Bonn, DE
- Sven Cichon
- 0 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, CH
- Sven Cichon
- 17 Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, DE
- Roel A Ophoff
- 0 Psychiatry, UMC Utrecht Hersencentrum Rudolf Magnus, Utrecht, NL
- Roel A Ophoff
- 1 Human Genetics, University of California Los Angeles, Los Angeles, CA, US
- Roel A Ophoff
- 1 Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, US
- Laura J Scott
- 8 Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, US
- Ole A Andreassen
- 35 Div Mental Health and Addiction, Oslo University Hospital, Oslo, NO
- Ole A Andreassen
- 36 NORMENT, University of Oslo, Oslo, NO
- John Kelsoe
- 0 Department of Psychiatry, University of California San Diego, La Jolla, CA, US
- John Kelsoe
- Co-last authors
- Pamela Sklar
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Pamela Sklar
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, US
- Pamela Sklar
- Co-last authors
- Pamela Sklar
- deceased
- DOI
- https://doi.org/10.3389/fnins.2019.00220
- Journal volume & issue
-
Vol. 13
Abstract
Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits.Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework.Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect).Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.
Keywords
