Sydnone derivatives as synthons for novel bismesoionic compounds.Synthesis of 3-(2-sulphido-1,3,4-thiadiazolium-4-carbonylphenyl) sydnones and 4-[4-(2-sulphido-1,3,4-thiadiazolium) benzoyl]-1,3,4-thiadiazolium-2-thiolates from 3-[4/3-(hydrazinocarbonyl)phenyl]sydnones, and their antimicrobial and antitubercular activities

Abstract

Some hitherto unknown novel bismesoionic compounds, 3-[4/3-(5H/substituted- 2-sulphido-1,3,4-thiadiazolium-4-carbonyl)phenyl]sydnones 5a–d and 6a-d and 4-[4-(5H/substituted-2-sulphido-1,3,4-thiadiazolium)benzoyl]-5H/substituted-1,3,4-thiadiazolium-2-thiolates 9a–d have been synthesized from 3-[(hydrazinocarbonyl)phenyl] sydnones 1 and 2. Afew of these compounds exhibited in vitro antitubercular activity and also antimicrobial activity higher than the employed reference drugs.

Keywords

• 3-[4/3-(hydrazinocarbonyl)phenyl]sydnones
• bismesoionic compounds