Urinary calprotectin and posttransplant renal allograft injury.

Abstract

ObjectiveCurrent methods do not predict the acute renal allograft injury immediately after kidney transplantation. We evaluated the diagnostic performance of urinary calprotectin for predicting immediate posttransplant allograft injury.MethodsIn a multicenter, prospective-cohort study of 144 incipient renal transplant recipients, we postoperatively measured urinary calprotectin using an enzyme-linked immunosorbent assay and estimated glomerular filtration rate (eGFR) after 4 weeks, 6 months, and 12 months.ResultsWe observed a significant inverse association of urinary calprotectin concentrations and eGFR 4 weeks after transplantation (Spearman r = -0.33; PConclusionsUrinary calprotectin is an early, noninvasive predictor of immediate renal allograft injury after kidney transplantation.