Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K/Akt signaling pathway in a rat model

Yao Rubin; Ren Lirong; Wang Shiyong; Zhang Ming; Yang Kaishun

doi:10.1515/tnsci-2021-0012

Translational Neuroscience (Mar 2021)

Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K/Akt signaling pathway in a rat model

Yao Rubin,
Ren Lirong,
Wang Shiyong,
Zhang Ming,
Yang Kaishun

Affiliations

Yao Rubin: Department of Spine Surgery, The First Affiliated Hospital of Dali University, Dali City, No. 32 Carlsberg Avenue, Yunnan, 671000, China
Ren Lirong: Department of Spine Surgery, The First Affiliated Hospital of Dali University, Dali City, No. 32 Carlsberg Avenue, Yunnan, 671000, China
Wang Shiyong: Department of Spine Surgery, The First Affiliated Hospital of Dali University, Dali City, No. 32 Carlsberg Avenue, Yunnan, 671000, China
Zhang Ming: Department of Spine Surgery, The First Affiliated Hospital of Dali University, Dali City, No. 32 Carlsberg Avenue, Yunnan, 671000, China
Yang Kaishun: Department of Spine Surgery, The First Affiliated Hospital of Dali University, Dali City, No. 32 Carlsberg Avenue, Yunnan, 671000, China

DOI: https://doi.org/10.1515/tnsci-2021-0012
Journal volume & issue: Vol. 12, no. 1
pp. 114 – 126

Abstract

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Owing to neurite promoting, antioxidant and anti-inflammatory effects of Euxanthone (Eux), the investigation was aimed to probe the neuroprotective efficacy of Eux against traumatic spinal cord injury (t-SCI) in rats and whether Eux can improve neuropathic function in t-SCI.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

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