Nature Communications (Apr 2020)
Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
- Jianquan Xu,
- Hongqiang Ma,
- Hongbin Ma,
- Wei Jiang,
- Christopher A. Mela,
- Meihan Duan,
- Shimei Zhao,
- Chenxi Gao,
- Eun-Ryeong Hahm,
- Santana M. Lardo,
- Kris Troy,
- Ming Sun,
- Reet Pai,
- Donna B. Stolz,
- Lin Zhang,
- Shivendra Singh,
- Randall E. Brand,
- Douglas J. Hartman,
- Jing Hu,
- Sarah J. Hainer,
- Yang Liu
Affiliations
- Jianquan Xu
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- Hongqiang Ma
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- Hongbin Ma
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- Wei Jiang
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- Christopher A. Mela
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- Meihan Duan
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- Shimei Zhao
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- Chenxi Gao
- Department of Pharmacology and Chemical Biology, University of Pittsburgh
- Eun-Ryeong Hahm
- Department of Pharmacology and Chemical Biology, University of Pittsburgh
- Santana M. Lardo
- Department of Biological Sciences, University of Pittsburgh
- Kris Troy
- Department of Biological Sciences, University of Pittsburgh
- Ming Sun
- Department of Cell Biology, University of Pittsburgh
- Reet Pai
- Department of Pathology, University of Pittsburgh School of Medicine
- Donna B. Stolz
- Department of Cell Biology, University of Pittsburgh
- Lin Zhang
- Department of Pharmacology and Chemical Biology, University of Pittsburgh
- Shivendra Singh
- Department of Pharmacology and Chemical Biology, University of Pittsburgh
- Randall E. Brand
- University of Pittsburgh Hillman Cancer Center
- Douglas J. Hartman
- Department of Pathology, University of Pittsburgh School of Medicine
- Jing Hu
- University of Pittsburgh Hillman Cancer Center
- Sarah J. Hainer
- Department of Biological Sciences, University of Pittsburgh
- Yang Liu
- Biomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh
- DOI
- https://doi.org/10.1038/s41467-020-15718-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.
