CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2

Haina Shin; Yosuke Kumamoto; Smita Gopinath; Akiko Iwasaki

doi:10.1038/ncomms13346

Nature Communications (Nov 2016)

CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2

Haina Shin,
Yosuke Kumamoto,
Smita Gopinath,
Akiko Iwasaki

Affiliations

Haina Shin: Department of Immunobiology, Yale University School of Medicine
Yosuke Kumamoto: Department of Immunobiology, Yale University School of Medicine
Smita Gopinath: Department of Immunobiology, Yale University School of Medicine
Akiko Iwasaki: Department of Immunobiology, Yale University School of Medicine

DOI: https://doi.org/10.1038/ncomms13346
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not circulating T cells, is central to HSV-2 resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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