Nature Communications (Jan 2020)

Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing

  • Arkaitz Ibarra,
  • Jiali Zhuang,
  • Yue Zhao,
  • Neeraj S. Salathia,
  • Vera Huang,
  • Alexander D. Acosta,
  • Jonathan Aballi,
  • Shusuke Toden,
  • Amy P. Karns,
  • Intan Purnajo,
  • Julianna R. Parks,
  • Lucy Guo,
  • James Mason,
  • Darren Sigal,
  • Tina S. Nova,
  • Stephen R. Quake,
  • Michael Nerenberg

DOI
https://doi.org/10.1038/s41467-019-14253-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Circulating cell-free mRNA holds great promise as a non-invasive diagnostic biomarker. Here the authors show that cell-free mRNA captures transcripts from the bone marrow and can be used to non-invasively monitor dynamic changes in bone marrow physiology.