Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

Henrik Jespersen; Mattias F. Lindberg; Marco Donia; Elin M. V. Söderberg; Rikke Andersen; Ulrich Keller; Lars Ny; Inge Marie Svane; Lisa M. Nilsson; Jonas A. Nilsson

doi:10.1038/s41467-017-00786-z

Nature Communications (Sep 2017)

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

Henrik Jespersen,
Mattias F. Lindberg,
Marco Donia,
Elin M. V. Söderberg,
Rikke Andersen,
Ulrich Keller,
Lars Ny,
Inge Marie Svane,
Lisa M. Nilsson,
Jonas A. Nilsson

Affiliations

Henrik Jespersen: From the Sahlgrenska Translational Melanoma Group, Institute of Clinical Science, Departments of Surgery and Oncology, Sahlgrenska Cancer Center at University of Gothenburg and Sahlgrenska University Hospital
Mattias F. Lindberg: From the Sahlgrenska Translational Melanoma Group, Institute of Clinical Science, Departments of Surgery and Oncology, Sahlgrenska Cancer Center at University of Gothenburg and Sahlgrenska University Hospital
Marco Donia: Center for Cancer Immune Therapy, Department of Hematology and Department of Oncology, Herlev Hospital, University of Copenhagen
Elin M. V. Söderberg: From the Sahlgrenska Translational Melanoma Group, Institute of Clinical Science, Departments of Surgery and Oncology, Sahlgrenska Cancer Center at University of Gothenburg and Sahlgrenska University Hospital
Rikke Andersen: Center for Cancer Immune Therapy, Department of Hematology and Department of Oncology, Herlev Hospital, University of Copenhagen
Ulrich Keller: Internal Medicine III, Technische Universität München
Lars Ny: From the Sahlgrenska Translational Melanoma Group, Institute of Clinical Science, Departments of Surgery and Oncology, Sahlgrenska Cancer Center at University of Gothenburg and Sahlgrenska University Hospital
Inge Marie Svane: Center for Cancer Immune Therapy, Department of Hematology and Department of Oncology, Herlev Hospital, University of Copenhagen
Lisa M. Nilsson: From the Sahlgrenska Translational Melanoma Group, Institute of Clinical Science, Departments of Surgery and Oncology, Sahlgrenska Cancer Center at University of Gothenburg and Sahlgrenska University Hospital
Jonas A. Nilsson: From the Sahlgrenska Translational Melanoma Group, Institute of Clinical Science, Departments of Surgery and Oncology, Sahlgrenska Cancer Center at University of Gothenburg and Sahlgrenska University Hospital

DOI: https://doi.org/10.1038/s41467-017-00786-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Combining different types of immune therapies might benefit certain patients. Here, the authors develop an autologous immune-humanized melanoma mouse model that allows the preclinical assessment of cancer cell–T cell interactions from each individual patient and the benefits of immunotherapies combinations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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