Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size

Runfeng Miao; Harim Chun; Xing Feng; Ana Cordeiro Gomes; Jungmin Choi; João P. Pereira

doi:10.1038/s41467-022-32228-w

Nature Communications (Aug 2022)

Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size

Runfeng Miao,
Harim Chun,
Xing Feng,
Ana Cordeiro Gomes,
Jungmin Choi,
João P. Pereira

Affiliations

Runfeng Miao: Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine
Harim Chun: BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine
Xing Feng: Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine
Ana Cordeiro Gomes: Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine
Jungmin Choi: BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine
João P. Pereira: Department of Immunobiology and Yale Stem Cell Center, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-32228-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Hematopoietic stem cells (HSCs) rely on a combination of paracrine signals produced by their niche, including SCF. Here the authors show that HSCs and hematopoietic progenitors compete for limited amounts of membrane-bound SCF.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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