Nature Communications (Feb 2022)
Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
- Nourhan Abdelfattah,
- Parveen Kumar,
- Caiyi Wang,
- Jia-Shiun Leu,
- William F. Flynn,
- Ruli Gao,
- David S. Baskin,
- Kumar Pichumani,
- Omkar B. Ijare,
- Stephanie L. Wood,
- Suzanne Z. Powell,
- David L. Haviland,
- Brittany C. Parker Kerrigan,
- Frederick F. Lang,
- Sujit S. Prabhu,
- Kristin M. Huntoon,
- Wen Jiang,
- Betty Y. S. Kim,
- Joshy George,
- Kyuson Yun
Affiliations
- Nourhan Abdelfattah
- Department of Neurology, Houston Methodist Research Institute
- Parveen Kumar
- The Jackson Laboratory for Genomic Medicine
- Caiyi Wang
- Department of Neurology, Houston Methodist Research Institute
- Jia-Shiun Leu
- Department of Neurology, Houston Methodist Research Institute
- William F. Flynn
- The Jackson Laboratory for Genomic Medicine
- Ruli Gao
- Center for Bioinformatics and Computational Biology. Houston Methodist Research Institute Houston
- David S. Baskin
- Department of Neurosurgery, Houston Methodist Neurological Institute
- Kumar Pichumani
- Department of Neurosurgery, Houston Methodist Neurological Institute
- Omkar B. Ijare
- Department of Neurosurgery, Houston Methodist Neurological Institute
- Stephanie L. Wood
- Department of Neurosurgery, Houston Methodist Neurological Institute
- Suzanne Z. Powell
- Kenneth R. Peak Center for Brain and Pituitary Tumor Treatment and Research, Department of Neurosurgery, Houston Methodist Neurological Institute
- David L. Haviland
- Flow Cytometry Core, Houston Methodist Research Institute
- Brittany C. Parker Kerrigan
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Frederick F. Lang
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Sujit S. Prabhu
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Kristin M. Huntoon
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Wen Jiang
- Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Betty Y. S. Kim
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Joshy George
- The Jackson Laboratory for Genomic Medicine
- Kyuson Yun
- Department of Neurology, Houston Methodist Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-28372-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Glioblastoma (GBM) is an immune cold tumour that is refractory to immunotherapy. Here, the authors identify molecular phenotypes of immune-suppressive and -promoting myeloid cells in GBM through single cell RNA sequencing and propose S100A4 as a regulator of immune suppressive T and myeloid cells in GBM.
