Dynamic Networks of Human Homeostatic Control in Norm

Abstract

The research has been undertaken to study the regional and common relationships between hemodynamic and metabolic parameters of human body functioning in individuals without clinical signs of pathology (in "norm"). Indicators of hemodynamics and metabolism were obtained by catheterization in a variety of areas: LV, RV, RA, CS, Ao, fixed SS, IJV, SVC, right VH, renal vena, and PA. Correlation and factor analyses were conducted for the study of: 1) the relationship between biochemical parameters in the blood stream, 2) the relationship between hemodynamic parameters, 3) relationship between the hemodynamic and biochemical parameters. Due to the nature of the correlation analysis, the significant (p<0.05) relation signs (+, 0, -) without regard to their power were considered. The obtained results in the study of brain blood flow, heart, liver, lungs, kidneys suggested the existence of the primary homeostatic control of the factors determining rheological and thrombogenic properties of blood; the regulation of brain gas exchange and intracranial venous pressure by the minimum level of pressure in the cerebral outflow pathway—the pressure in RA; the regulating relationships between blood flow in CS with blood flow in HV, RA, SS, and LV; and the existence of a synergistic complex of the relationships between the studied biochemical and hemodynamic characteristics that form the human homeostasis control matrix in norm.

Keywords

• human homeostasis control matrix;
• hydrodynamic balance;
• hepatic venous outflow;
• coronary sinus