Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

Mulki Angela; Yusuke Endo; Hikari K. Asou; Takeshi Yamamoto; Damon J. Tumes; Hirotake Tokuyama; Koutaro Yokote; Toshinori Nakayama

doi:10.1038/ncomms13683

Nature Communications (Nov 2016)

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

Mulki Angela,
Yusuke Endo,
Hikari K. Asou,
Takeshi Yamamoto,
Damon J. Tumes,
Hirotake Tokuyama,
Koutaro Yokote,
Toshinori Nakayama

Affiliations

Mulki Angela: Department of Immunology, Graduate School of Medicine, Chiba University
Yusuke Endo: Department of Immunology, Graduate School of Medicine, Chiba University
Hikari K. Asou: Department of Immunology, Graduate School of Medicine, Chiba University
Takeshi Yamamoto: Department of Immunology, Graduate School of Medicine, Chiba University
Damon J. Tumes: Department of Immunology, Graduate School of Medicine, Chiba University
Hirotake Tokuyama: Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University
Koutaro Yokote: Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University
Toshinori Nakayama: Department of Immunology, Graduate School of Medicine, Chiba University

DOI: https://doi.org/10.1038/ncomms13683
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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