Nature Communications (Jun 2021)

Critical angle reflection imaging for quantification of molecular interactions on glass surface

  • Guangzhong Ma,
  • Runli Liang,
  • Zijian Wan,
  • Shaopeng Wang

DOI
https://doi.org/10.1038/s41467-021-23730-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

Read online

Here, the authors present a method for quantifying molecular interactions on a glass surface, based on measuring surface refractive index changes via the reflectivity near the critical angle. They demonstrate tunable sensitivity and dynamic range, deep vertical sensing range, also for intracellular signals.