Nature Communications (Feb 2021)
Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity
- Matthias Becker,
- Monika Strengert,
- Daniel Junker,
- Philipp D. Kaiser,
- Tobias Kerrinnes,
- Bjoern Traenkle,
- Heiko Dinter,
- Julia Häring,
- Stéphane Ghozzi,
- Anne Zeck,
- Frank Weise,
- Andreas Peter,
- Sebastian Hörber,
- Simon Fink,
- Felix Ruoff,
- Alex Dulovic,
- Tamam Bakchoul,
- Armin Baillot,
- Stefan Lohse,
- Markus Cornberg,
- Thomas Illig,
- Jens Gottlieb,
- Sigrun Smola,
- André Karch,
- Klaus Berger,
- Hans-Georg Rammensee,
- Katja Schenke-Layland,
- Annika Nelde,
- Melanie Märklin,
- Jonas S. Heitmann,
- Juliane S. Walz,
- Markus Templin,
- Thomas O. Joos,
- Ulrich Rothbauer,
- Gérard Krause,
- Nicole Schneiderhan-Marra
Affiliations
- Matthias Becker
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Monika Strengert
- Department of Epidemiology, Helmholtz Centre for Infection Research
- Daniel Junker
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Philipp D. Kaiser
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Tobias Kerrinnes
- Helmholtz-Institute for RNA-based Infection Research (HIRI)
- Bjoern Traenkle
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Heiko Dinter
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Julia Häring
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Stéphane Ghozzi
- Department of Epidemiology, Helmholtz Centre for Infection Research
- Anne Zeck
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Frank Weise
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Andreas Peter
- Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen
- Sebastian Hörber
- Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen
- Simon Fink
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Felix Ruoff
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Alex Dulovic
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Tamam Bakchoul
- Institute for Clinical and Experimental Transfusion Medicine, University Hospital Tübingen
- Armin Baillot
- Niedersächsisches Landesgesundheitsamt, Department of Virology/Serology
- Stefan Lohse
- Institute of Virology, Saarland University Medical Center
- Markus Cornberg
- Department of Gastroenterology, Hepatology, Endocrinology, Hannover Medical School, Hannover, Germany; Centre for Individualized Infection Medicine (CiiM)
- Thomas Illig
- Hannover Unified Biobank (HUB), Hannover Medical School
- Jens Gottlieb
- Department of Respiratory Medicine, Hannover Medical School
- Sigrun Smola
- Institute of Virology, Saarland University Medical Center
- André Karch
- Institute of Epidemiology and Social Medicine, University of Münster
- Klaus Berger
- Institute of Epidemiology and Social Medicine, University of Münster
- Hans-Georg Rammensee
- Institute for Cell Biology, Department of Immunology, University of Tübingen
- Katja Schenke-Layland
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Annika Nelde
- Institute for Cell Biology, Department of Immunology, University of Tübingen
- Melanie Märklin
- Cluster of Excellence iFIT (EXC2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tübingen
- Jonas S. Heitmann
- Cluster of Excellence iFIT (EXC2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tübingen
- Juliane S. Walz
- Institute for Cell Biology, Department of Immunology, University of Tübingen
- Markus Templin
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Thomas O. Joos
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Ulrich Rothbauer
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Gérard Krause
- Department of Epidemiology, Helmholtz Centre for Infection Research
- Nicole Schneiderhan-Marra
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- DOI
- https://doi.org/10.1038/s41467-021-20973-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Serology is an important way to monitor SARS-CoV-2 infection in the population and support vaccine development. Here the authors develop a multiplex immunoassay including spike and nucleocapsid proteins of SARS-CoV-2 and the endemic human coronaviruses with high specificity and sensitivity.
