Club 35, Polish Society of Gynecologists and Obstetricians, 53-125 Wrocław, Poland
Damian Warzecha
I Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Robert Spaczyński
Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-512 Poznan, Poland
Piotr Piekarski
Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 60-512 Poznan, Poland
Beata Banaszewska
Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, 60-512 Poznan, Poland
Artur Jakimiuk
Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland
Tadeusz Issat
Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland
Wojciech Rokita
Collegium Medicum, Jan Kochanowski University in Kielce, 25-369 Kielce, Poland
Jakub Młodawski
Collegium Medicum, Jan Kochanowski University in Kielce, 25-369 Kielce, Poland
Maria Szubert
Club 35, Polish Society of Gynecologists and Obstetricians, 53-125 Wrocław, Poland
Piotr Sieroszewski
Department of Gynecology and Obstetrics, Medical University of Lodz, 90-419 Lodz, Poland
Grzegorz Raba
Clinic of Obstetrics and Gynecology in Przemysl, 37-700 Przemysl, Poland
Kamil Szczupak
Clinic of Obstetrics and Gynecology in Przemysl, 37-700 Przemysl, Poland
Tomasz Kluz
Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland
Marek Kluza
Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland
Krzysztof Czajkowski
II Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Mirosław Wielgoś
I Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Ewa Koc-Żórawska
II Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, 15-089 Bialystok, Poland
Marcin Żórawski
Department of Clinical Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland
Piotr Laudański
I Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-091 Warsaw, Poland
The evidence of poly (ADP-ribose) polymerase (PARP) association with the immune response could be coherent with the immunological theory of endometriosis and suggests the possibility of a new research direction. The aim of the study was to evaluate the levels of PARP in plasma and peritoneal fluid of patients with and without endometriosis. It was a multicenter, cross-sectional study. Plasma and peritoneal fluid samples were collected from patients with and without endometriosis during planned laparoscopic procedures in eight clinical centers. In total, 84 samples of plasma and 84 samples of the peritoneal fluid were included in the final analyses. Double-antibody sandwich enzyme-linked immunosorbent assay was performed in order to assess levels of PARP in collected samples. No statistically significant differences regarding the detected levels of PARP in plasma and peritoneal fluid comparing patients with and without endometriosis were observed. Patients with a history of infertility had significantly higher plasma PARP concentrations (p = 0.04). We have not observed the potential role of PARP concentration levels in plasma nor peritoneal fluid as an endometriosis biomarker. We have determined an association between a higher plasma PARP concentration and a history of infertility.
