Memorias do Instituto Oswaldo Cruz (Mar 2021)

Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

  • Emilyn Costa Conceição,
  • Richard Steiner Salvato,
  • Karen Machado Gomes,
  • Arthur Emil dos Santos Guimarães,
  • Marília Lima da Conceição,
  • Ricardo José de Paula Souza e Guimarães,
  • Abhinav Sharma,
  • Ismari Perini Furlaneto,
  • Regina Bones Barcellos,
  • Valdes Roberto Bollela,
  • Lívia Maria Pala Anselmo,
  • Maria Carolina Sisco,
  • Cristina Viana Niero,
  • Lucilaine Ferrazoli,
  • Guislaine Refrégier,
  • Maria Cristina da Silva Lourenço,
  • Harrison Magdinier Gomes,
  • Artemir Coelho de Brito,
  • Marcos Catanho,
  • Rafael Silva Duarte,
  • Philip Noel Suffys,
  • Karla Valéria Batista Lima

DOI
https://doi.org/10.1590/0074-02760200517
Journal volume & issue
Vol. 116

Abstract

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Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.

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