Mechanism of TUDCA for retinitis pigmentosa

Li Yuan; Yan Liu

doi:10.3980/j.issn.1672-5123.2018.8.10

Guoji Yanke Zazhi (Aug 2018)

Mechanism of TUDCA for retinitis pigmentosa

Li Yuan,
Yan Liu

Affiliations

Li Yuan: Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China
Yan Liu: Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China

DOI: https://doi.org/10.3980/j.issn.1672-5123.2018.8.10
Journal volume & issue: Vol. 18, no. 8
pp. 1403 – 1406

Abstract

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Tauroursodeoxycholic acid(TUDCA)is formed by taurine conjugated of ursodeoxycholic acid(UDCA). It has the role of neurotrophic factor in anti-inflammatory, anti-apoptosis and reducing the activation of microglial cells. These effects may be one of the most critical of all pathological stages of retinitis pigmentosa. Preclinical trials have shown that TUDCA had potential therapeutic value for retinal degeneration disease. This article discusses how TUDCA can slow down the process of retinal degeneration.

Published in Guoji Yanke Zazhi

ISSN: 1672-5123 (Print)
Publisher: Press of International Journal of Ophthalmology (IJO PRESS)
Country of publisher: China
LCC subjects: Medicine: Ophthalmology
Website: http://ies.ijo.cn/

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