Nature Communications (Feb 2021)
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
- Francisco J. Salguero,
- Andrew D. White,
- Gillian S. Slack,
- Susan A. Fotheringham,
- Kevin R. Bewley,
- Karen E. Gooch,
- Stephanie Longet,
- Holly E. Humphries,
- Robert J. Watson,
- Laura Hunter,
- Kathryn A. Ryan,
- Yper Hall,
- Laura Sibley,
- Charlotte Sarfas,
- Lauren Allen,
- Marilyn Aram,
- Emily Brunt,
- Phillip Brown,
- Karen R. Buttigieg,
- Breeze E. Cavell,
- Rebecca Cobb,
- Naomi S. Coombes,
- Alistair Darby,
- Owen Daykin-Pont,
- Michael J. Elmore,
- Isabel Garcia-Dorival,
- Konstantinos Gkolfinos,
- Kerry J. Godwin,
- Jade Gouriet,
- Rachel Halkerston,
- Debbie J. Harris,
- Thomas Hender,
- Catherine M. K. Ho,
- Chelsea L. Kennard,
- Daniel Knott,
- Stephanie Leung,
- Vanessa Lucas,
- Adam Mabbutt,
- Alexandra L. Morrison,
- Charlotte Nelson,
- Didier Ngabo,
- Jemma Paterson,
- Elizabeth J. Penn,
- Steve Pullan,
- Irene Taylor,
- Tom Tipton,
- Stephen Thomas,
- Julia A. Tree,
- Carrie Turner,
- Edith Vamos,
- Nadina Wand,
- Nathan R. Wiblin,
- Sue Charlton,
- Xiaofeng Dong,
- Bassam Hallis,
- Geoffrey Pearson,
- Emma L. Rayner,
- Andrew G. Nicholson,
- Simon G. Funnell,
- Julian A. Hiscox,
- Mike J. Dennis,
- Fergus V. Gleeson,
- Sally Sharpe,
- Miles W. Carroll
Affiliations
- Francisco J. Salguero
- National Infection Service, Public Health England (PHE)
- Andrew D. White
- National Infection Service, Public Health England (PHE)
- Gillian S. Slack
- National Infection Service, Public Health England (PHE)
- Susan A. Fotheringham
- National Infection Service, Public Health England (PHE)
- Kevin R. Bewley
- National Infection Service, Public Health England (PHE)
- Karen E. Gooch
- National Infection Service, Public Health England (PHE)
- Stephanie Longet
- National Infection Service, Public Health England (PHE)
- Holly E. Humphries
- National Infection Service, Public Health England (PHE)
- Robert J. Watson
- National Infection Service, Public Health England (PHE)
- Laura Hunter
- National Infection Service, Public Health England (PHE)
- Kathryn A. Ryan
- National Infection Service, Public Health England (PHE)
- Yper Hall
- National Infection Service, Public Health England (PHE)
- Laura Sibley
- National Infection Service, Public Health England (PHE)
- Charlotte Sarfas
- National Infection Service, Public Health England (PHE)
- Lauren Allen
- National Infection Service, Public Health England (PHE)
- Marilyn Aram
- National Infection Service, Public Health England (PHE)
- Emily Brunt
- National Infection Service, Public Health England (PHE)
- Phillip Brown
- National Infection Service, Public Health England (PHE)
- Karen R. Buttigieg
- National Infection Service, Public Health England (PHE)
- Breeze E. Cavell
- National Infection Service, Public Health England (PHE)
- Rebecca Cobb
- National Infection Service, Public Health England (PHE)
- Naomi S. Coombes
- National Infection Service, Public Health England (PHE)
- Alistair Darby
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Owen Daykin-Pont
- National Infection Service, Public Health England (PHE)
- Michael J. Elmore
- National Infection Service, Public Health England (PHE)
- Isabel Garcia-Dorival
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Konstantinos Gkolfinos
- National Infection Service, Public Health England (PHE)
- Kerry J. Godwin
- National Infection Service, Public Health England (PHE)
- Jade Gouriet
- National Infection Service, Public Health England (PHE)
- Rachel Halkerston
- National Infection Service, Public Health England (PHE)
- Debbie J. Harris
- National Infection Service, Public Health England (PHE)
- Thomas Hender
- National Infection Service, Public Health England (PHE)
- Catherine M. K. Ho
- National Infection Service, Public Health England (PHE)
- Chelsea L. Kennard
- National Infection Service, Public Health England (PHE)
- Daniel Knott
- National Infection Service, Public Health England (PHE)
- Stephanie Leung
- National Infection Service, Public Health England (PHE)
- Vanessa Lucas
- National Infection Service, Public Health England (PHE)
- Adam Mabbutt
- National Infection Service, Public Health England (PHE)
- Alexandra L. Morrison
- National Infection Service, Public Health England (PHE)
- Charlotte Nelson
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Didier Ngabo
- National Infection Service, Public Health England (PHE)
- Jemma Paterson
- National Infection Service, Public Health England (PHE)
- Elizabeth J. Penn
- National Infection Service, Public Health England (PHE)
- Steve Pullan
- National Infection Service, Public Health England (PHE)
- Irene Taylor
- National Infection Service, Public Health England (PHE)
- Tom Tipton
- National Infection Service, Public Health England (PHE)
- Stephen Thomas
- National Infection Service, Public Health England (PHE)
- Julia A. Tree
- National Infection Service, Public Health England (PHE)
- Carrie Turner
- National Infection Service, Public Health England (PHE)
- Edith Vamos
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Nadina Wand
- National Infection Service, Public Health England (PHE)
- Nathan R. Wiblin
- National Infection Service, Public Health England (PHE)
- Sue Charlton
- National Infection Service, Public Health England (PHE)
- Xiaofeng Dong
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Bassam Hallis
- National Infection Service, Public Health England (PHE)
- Geoffrey Pearson
- National Infection Service, Public Health England (PHE)
- Emma L. Rayner
- National Infection Service, Public Health England (PHE)
- Andrew G. Nicholson
- Royal Brompton and Harefield NHS Foundation Trust, and National Heart and Lung Institute, Imperial College
- Simon G. Funnell
- National Infection Service, Public Health England (PHE)
- Julian A. Hiscox
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Mike J. Dennis
- National Infection Service, Public Health England (PHE)
- Fergus V. Gleeson
- Department of Oncology, Oxford University
- Sally Sharpe
- National Infection Service, Public Health England (PHE)
- Miles W. Carroll
- National Infection Service, Public Health England (PHE)
- DOI
- https://doi.org/10.1038/s41467-021-21389-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung histopathology scoring system.
