Association of Waist-Height Ratio with Diabetes Risk: A 4-Year Longitudinal Retrospective Study

Endocrinology and Metabolism. 2016;31(1):127-133 DOI 10.3803/EnM.2016.31.1.127


Journal Homepage

Journal Title: Endocrinology and Metabolism

ISSN: 2093-596X (Print); 2093-5978 (Online)

Publisher: Academya Publishing Co.

Society/Institution: Korean Endocrine Society

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology

Country of publisher: Korea, Republic of

Language of fulltext: Korean, English

Full-text formats available: PDF, ePUB, PubReader



Yoon Jeong Son
Jihyun Kim
Hye-Jeong Park
Se Eun Park
Cheol-Young Park
Won-Young Lee
Ki-Won Oh
Sung-Woo Park
Eun-Jung Rhee


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 24 weeks


Abstract | Full Text

BackgroundWaist-to-height ratio (WHtR) is an easy and inexpensive adiposity index that reflects central obesity. In this study, we examined the association of various baseline adiposity indices, including WHtR, with the development of diabetes over 4 years of follow-up in apparently healthy Korean individuals.MethodsA total of 2,900 nondiabetic participants (mean age, 44.3 years; 2,078 men) in a health screening program, who repeated the medical check-up in 2005 and 2009, were recruited. Subjects were divided into two groups according to development of diabetes after 4 years. The cut-off values of baseline body mass index (BMI), waist circumference (WC), and WHtR for the development of diabetes over 4 years were calculated. The sensitivity, specificity, and mean area under the receiver operator characteristic curve (AUROC) of each index were assessed. The odds ratio (OR) for diabetes development was analyzed for each of the three baseline adiposity indices.ResultsDuring the follow-up period, 101 new cases (3.5%) of diabetes were diagnosed. The cut-off WHtR value for diabetes development was 0.51. Moreover, WHtR had the highest AUROC value for diabetes development among the three adiposity indices (0.716, 95% confidence interval [CI], 0.669 to 0.763; 0.702, 95% CI, 0.655 to 0.750 for WC; 0.700, 95% CI, 0.651 to 0.750 for BMI). After adjusting for confounding variables, the ORs of WHtR and WC for diabetes development were 1.95 (95% CI, 1.14 to 3.34) and 1.96 (95% CI, 1.10 to 3.49), respectively. No significant differences were observed between the two groups regarding BMI.ConclusionIncreased baseline WHtR and WC correlated with the development of diabetes after 4 years. WHtR might be a useful screening measurement to identify individuals at high risk for diabetes.