LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Bhupender Yadav; Sonali Pal; Yury Rubstov; Akul Goel; Manoj Garg; Marat Pavlyukov; Amit Kumar Pandey

doi:10.1016/j.omtn.2021.03.018

Molecular Therapy: Nucleic Acids (Jun 2021)

LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Bhupender Yadav,
Sonali Pal,
Yury Rubstov,
Akul Goel,
Manoj Garg,
Marat Pavlyukov,
Amit Kumar Pandey

Affiliations

Bhupender Yadav: Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India
Sonali Pal: Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India
Yury Rubstov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation; Faculty of Biology and Biotechnology, National Research University Higher School of Economics, Vavilova Street 7, 117312 Moscow, Russian Federation
Akul Goel: La Canada High School, La Canada Flintridge, CA 91011, USA
Manoj Garg: Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University, Uttar Pradesh, Sector 125, Noida 201313, India
Marat Pavlyukov: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation
Amit Kumar Pandey: Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India; Corresponding author: Amit Kumar Pandey, Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India.

DOI: https://doi.org/10.1016/j.omtn.2021.03.018
Journal volume & issue: Vol. 24
pp. 728 – 742

Abstract

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Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.

Published in Molecular Therapy: Nucleic Acids

ISSN: 2162-2531 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.cell.com/molecular-therapy-family/nucleic-acids/latest-content

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