Idiopathic Hypereosinophilia and Venous Thromboembolism: Is There a Pathophysiological or Clinical Link? Description of an Intriguing Clinical Case

Abstract

Pierpaolo Di Micco,1 Olga Scudiero,2,3 Barbara Lombardo,2,3 Corrado Lodigiani4 1Department of Internal Medicine and Emergency Room, Fatebenefratelli Hospital of Naples, Naples, Italy; 2Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, Napoli, Italia; 3CEINGE-Biotecnologie Avanzate, Napoli, Italia; 4Thrombosis and Hemorrhagic Center, Humanitas Research Hospital and Humanitas University, Rozzano, ItalyCorrespondence: Corrado LodigianiThrombosis and Hemorrhagic Center, Humanitas Research Hospital and Humanitas University, Rozzano, ItalyEmail [email protected]: Thrombosis events usually occur after prolonged bedrest, pregnancy, hormonal therapy, recent surgery and in the presence of inherited or acquired thrombophilia. However, several other diseases are often associated with thrombosis although their frequency is not easily estimated. Eosinophilia is one of these conditions. From a clinical viewpoint it is very difficult to understand which conditions might lead to a thrombotic event because the underlying pathophysiological mechanisms are different. Here, we report a case of idiopathic hypereosinophilia associated to venous thromboembolism without any other associated prothrombotic condition.Keywords: venous thromboembolism, deep vein thrombosis, hypereosinophilia, allergy

Keywords

• venous thromboembolism
• deep vein thrombosis
• hypereosinophilia
• allergy