Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

Arnau Vich Vila; Valerie Collij; Serena Sanna; Trishla Sinha; Floris Imhann; Arno R. Bourgonje; Zlatan Mujagic; Daisy M. A. E. Jonkers; Ad A. M. Masclee; Jingyuan Fu; Alexander Kurilshikov; Cisca Wijmenga; Alexandra Zhernakova; Rinse K. Weersma

doi:10.1038/s41467-019-14177-z

Nature Communications (Jan 2020)

Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

Arnau Vich Vila,
Valerie Collij,
Serena Sanna,
Trishla Sinha,
Floris Imhann,
Arno R. Bourgonje,
Zlatan Mujagic,
Daisy M. A. E. Jonkers,
Ad A. M. Masclee,
Jingyuan Fu,
Alexander Kurilshikov,
Cisca Wijmenga,
Alexandra Zhernakova,
Rinse K. Weersma

Affiliations

Arnau Vich Vila: Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Valerie Collij: Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Serena Sanna: Dept. of Genetics, University of Groningen and University Medical Center Groningen
Trishla Sinha: Dept. of Genetics, University of Groningen and University Medical Center Groningen
Floris Imhann: Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Arno R. Bourgonje: Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen
Zlatan Mujagic: Division Gastroenterology Hepatology, Maastricht University Medical Center
Daisy M. A. E. Jonkers: Division Gastroenterology Hepatology, Maastricht University Medical Center
Ad A. M. Masclee: Division Gastroenterology Hepatology, Maastricht University Medical Center
Jingyuan Fu: Dept. of Genetics, University of Groningen and University Medical Center Groningen
Alexander Kurilshikov: Dept. of Genetics, University of Groningen and University Medical Center Groningen
Cisca Wijmenga: Dept. of Genetics, University of Groningen and University Medical Center Groningen
Alexandra Zhernakova: Dept. of Genetics, University of Groningen and University Medical Center Groningen
Rinse K. Weersma: Dept. of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen

DOI: https://doi.org/10.1038/s41467-019-14177-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

Here, via a metagenomics analysis of population-based and disease cohorts, Vich Vila et al. study the impact of 41 commonly used medications on the taxonomic structures, metabolic potential and resistome of the gut microbiome, underscoring the importance of correcting for multiple drug use in microbiome studies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal