Nature Communications (May 2019)
LNK suppresses interferon signaling in melanoma
- Ling-Wen Ding,
- Qiao-Yang Sun,
- Jarem J. Edwards,
- Lucia Torres Fernández,
- Xue-Bin Ran,
- Si-Qin Zhou,
- Richard A. Scolyer,
- James S. Wilmott,
- John F. Thompson,
- Ngan Doan,
- Jonathan W. Said,
- Nachiyappan Venkatachalam,
- Jin-Fen Xiao,
- Xin-Yi Loh,
- Maren Pein,
- Liang Xu,
- David W. Mullins,
- Henry Yang,
- De-Chen Lin,
- H. Phillip Koeffler
Affiliations
- Ling-Wen Ding
- Cancer Science Institute of Singapore, National University of Singapore
- Qiao-Yang Sun
- Cancer Science Institute of Singapore, National University of Singapore
- Jarem J. Edwards
- Melanoma Institute Australia, The University of Sydney
- Lucia Torres Fernández
- Cancer Science Institute of Singapore, National University of Singapore
- Xue-Bin Ran
- Cancer Science Institute of Singapore, National University of Singapore
- Si-Qin Zhou
- Cancer Science Institute of Singapore, National University of Singapore
- Richard A. Scolyer
- Melanoma Institute Australia, The University of Sydney
- James S. Wilmott
- Melanoma Institute Australia, The University of Sydney
- John F. Thompson
- Melanoma Institute Australia, The University of Sydney
- Ngan Doan
- Santa Monica-University of California, Los Angeles Medical Center
- Jonathan W. Said
- Santa Monica-University of California, Los Angeles Medical Center
- Nachiyappan Venkatachalam
- Cancer Science Institute of Singapore, National University of Singapore
- Jin-Fen Xiao
- Cancer Science Institute of Singapore, National University of Singapore
- Xin-Yi Loh
- Cancer Science Institute of Singapore, National University of Singapore
- Maren Pein
- Cancer Science Institute of Singapore, National University of Singapore
- Liang Xu
- Cancer Science Institute of Singapore, National University of Singapore
- David W. Mullins
- Departments of Medical Education and Microbiology/Immunology, Geisel School of Medicine at Dartmouth
- Henry Yang
- Cancer Science Institute of Singapore, National University of Singapore
- De-Chen Lin
- Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine
- H. Phillip Koeffler
- Cancer Science Institute of Singapore, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-019-09711-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here, the authors show that the overexpression of LNK in melanomas correlate with hyperactive signaling of the RAS-RAF-MEK pathway and LNK enhances melanoma growth and survival and immune evasion by inhibiting IFN signalling.
