Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Yeonkyoung Park; Joori Park; Hyun Jung Hwang; Byungju Kim; Kwon Jeong; Jeeyoon Chang; Jong-Bong Lee; Yoon Ki Kim

doi:10.1038/s41467-020-16939-6

Nature Communications (Jun 2020)

Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Yeonkyoung Park,
Joori Park,
Hyun Jung Hwang,
Byungju Kim,
Kwon Jeong,
Jeeyoon Chang,
Jong-Bong Lee,
Yoon Ki Kim

Affiliations

Yeonkyoung Park: Creative Research Initiatives Center for Molecular Biology of Translation, Korea University
Joori Park: Creative Research Initiatives Center for Molecular Biology of Translation, Korea University
Hyun Jung Hwang: Creative Research Initiatives Center for Molecular Biology of Translation, Korea University
Byungju Kim: Department of Physics, Pohang University of Science and Technology (POSTECH)
Kwon Jeong: Creative Research Initiatives Center for Molecular Biology of Translation, Korea University
Jeeyoon Chang: Creative Research Initiatives Center for Molecular Biology of Translation, Korea University
Jong-Bong Lee: Department of Physics, Pohang University of Science and Technology (POSTECH)
Yoon Ki Kim: Creative Research Initiatives Center for Molecular Biology of Translation, Korea University

DOI: https://doi.org/10.1038/s41467-020-16939-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated misfolded polypeptides are cleared through autophagy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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