Reno-protective effects of fresh garlic against high fat diet induced damage

Abstract

Background: Hyperlipidemia remains one of most challenging clinical problems. Garlic used to lower serum lipids in hyperlipidemia patients. The present experimental study evaluate garlic role as reno-protective against high fat diet (HFD) induced changes in rat’s kidney. Methods: Twenty four adult albino rats were used and sorted into 4 groups. Group 1 (Control): fed normal lab diet. Group 2 (HFD): fed 6% highly saturated fat diet. Group 3 (GJ): received 20% of fresh crushed garlic per diet for 8 weeks. Group 4 (HFD+GJ): received 20% fresh crushed garlic with 6% highly saturated fat diet. Lipid profiles and kidney function tests were evaluated in the serum and kidneys were examined histologically. Results: Serum levels of total cholesterol, triglyceride, low density lipoprotein cholesterol, creatinine, uric acid, and blood urea nitrogen were higher; while total proteins and albumin were lower in HFD versus control, GJ, HFD+GJ groups. HFD resulted in degenerative changes of Bowman’s corpuscles and glomerular capillaries atrophy, renal tubules vacuolation that were ameliorated by garlic intake. Conclusions: Oral fresh garlic administration for 8 weeks with HFD group led to improvement of lipid profile, kidney functions and structure. Consumption of garlic juice could work as supplement and advised for protecting kidneys in hyperlipidemic patients.

Keywords

• biochemical analysis
• garlic juice
• high fat diet
• kidney function tests
• lipid profile