Oxidative Stress Levels of Serum and Urine in Enuresis

Abstract

INTRODUCTION: Enuresis is one of the most frequent psycho-social problems affecting self-esteem and life quality of child in childhood period. In this study, it was aimed to evaluate both systemic and local oxidant-antioxidant balance in primary enuresis by assessing oxidative stress level of serum and urine together. METHODS: A total of 106 individuals (36 patients with polysymptomatic nocturnal enuresis (polyNE), 35 patients with monosymptomatic nocturnal enuresis (monoNE), and 35 healthy controls), who were aged between 8-18 years and diagnosed with primary enuresis, were included in the study. Serum and urine Total Oxidant Status (TOS) and Total Antioxidant Status (TAS) levels and creatinine levels from urine samples of all participants were studied. Oxidative stress index (OSI) in all samples and TOS/cre and TAS/cre values in urine samples were calculated. RESULTS: In urine TOS/cre results, values of polyNE (2.459+-2.441) and monoNE (1.982+-1.402) groups were higher than control (1.251+-0.916) group(p=0.019)in a statistically significant manner. When urine OSI results were compared; it was found that polyNE (0.196+-0.153) and monoNE (0.192+-0.192) urine OSI values were higher than control group (0.123+-0.155)(p=0.04 )in a statistically significant manner. DISCUSSION AND CONCLUSION: In this study, we found that urinary oxidative stress level increased without any change in the serum oxidative stress level in enuretics which makes us think that local factors related to bladder in enuresis are more important and we can assert that bladder problems may trigger more problems in the future. Therefore, we believe that supportive treatment in enuresis should be started much sooner and more effective new treatment methods should be developed.

Keywords

• primary enuresis
• oxidative stress
• urine total oxidant status
• urine total antioxidant status
• urine oxidative stress index