Frontiers in Neurology (Jan 2021)
Concurrency of Early-Age Exposure to Chinese Famine and Diabetes Increases Recurrence of Ischemic Stroke
- Yue Suo,
- Yue Suo,
- Yue Suo,
- Yue Suo,
- Weiqi Chen,
- Weiqi Chen,
- Weiqi Chen,
- Weiqi Chen,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Yuesong Pan,
- Hao Li,
- Hao Li,
- Hao Li,
- Hao Li,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Xia Meng,
- Zixiao Li,
- Zixiao Li,
- Zixiao Li,
- Zixiao Li,
- Chunjuan Wang,
- Chunjuan Wang,
- Chunjuan Wang,
- Chunjuan Wang,
- Jing Jing,
- Jing Jing,
- Jing Jing,
- Jing Jing,
- Yilong Wang,
- Yilong Wang,
- Yilong Wang,
- Yilong Wang,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang
Affiliations
- Yue Suo
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yue Suo
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yue Suo
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yue Suo
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Weiqi Chen
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Weiqi Chen
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Weiqi Chen
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Weiqi Chen
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yuesong Pan
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yuesong Pan
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yuesong Pan
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yuesong Pan
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Hao Li
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Hao Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Hao Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Hao Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Xia Meng
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Xia Meng
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Xia Meng
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Xia Meng
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Zixiao Li
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Zixiao Li
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Zixiao Li
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Zixiao Li
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Chunjuan Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Chunjuan Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Chunjuan Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Chunjuan Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Jing Jing
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Jing Jing
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Jing Jing
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Jing Jing
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yilong Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yilong Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yilong Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yilong Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- Yongjun Wang
- Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- Yongjun Wang
- China National Clinical Research Center for Neurological Diseases, Beijing, China
- Yongjun Wang
- Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
- Yongjun Wang
- Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
- DOI
- https://doi.org/10.3389/fneur.2020.520633
- Journal volume & issue
-
Vol. 11
Abstract
Background and Purpose: Early age exposure to the Chinese Great Leap Forward famine (1959–1961) is associated with the incidence of risk factors for ischemic stroke. This study aims to examine the relationship between early age famine exposure and 12-month stroke recurrence. We sought to explore the interaction between famine exposure status and metabolic phenotypes on stroke recurrence and how the adherence of crucial evidence-based key performance indicators (KPI) would modify this interaction.Methods: We analyzed data of patients who were born between 1953 and 1964 in the China National Stroke Registry II (CNSR-II). The study population was further divided into five subgroups for comparing 12-month stroke recurrence. A multivariate Cox proportional hazard regression model was used in analyzing the impact of the concurrence of metabolic phenotypes—type 2 diabetes (T2D) or metabolic syndrome (MetS)—and early-age famine exposure on recurrent risk. The influence of the adherence to predefined KPI and concurrency of metabolic phenotype was also evaluated.Results: Concurrent T2D and early age famine exposure was associated with an increased recurrence risk of ischemic stroke with 12 months [adjusted hazard ratio (HR): 1.63, 95% confidence interval (CI) 1.28–2.07]. Optimal adherence to KPI was not associated with significantly reduced risk of 12-month stroke recurrence (adjusted HR: 0.80, 95% CI: 0.51–1.26).Conclusions: Concurrency of early-age famine exposure and diabetes mellitus was associated with a higher risk of stroke recurrence within 12 months, and adherence to evidence-based KPI did not reduce the risk significantly.
Keywords