Nature Communications (Aug 2020)

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

  • Benjamin Salzer,
  • Christina M. Schueller,
  • Charlotte U. Zajc,
  • Timo Peters,
  • Michael A. Schoeber,
  • Boris Kovacic,
  • Michelle C. Buri,
  • Elisabeth Lobner,
  • Omer Dushek,
  • Johannes B. Huppa,
  • Christian Obinger,
  • Eva M. Putz,
  • Wolfgang Holter,
  • Michael W. Traxlmayr,
  • Manfred Lehner

DOI
https://doi.org/10.1038/s41467-020-17970-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The lack of tumour-specific antigens and control over T-cell activity limits the development of CAR-T cell therapies for solid tumours. Here the authors present an avidity-controlled CAR platform with inducible logic control functions.