Kidney transplantation in the presence of pulmonary hypertension: A clinical dilemma

Abstract

End-stage renal disease (ESRD) is a progressive chronic condition that is strongly associated with cardiovascular mortality. ESRD patients usually benefit significantly from kidney transplantation. Pulmonary hypertension (PH) is a common finding in ESRD patients that adversely affects their survival. It has also been associated with adverse increased mortality and morbidity following kidney transplantation. However, PH has also been thought to improve following kidney transplantation. The exact underlying pathophysiology of PH in ESRD patients is unknown. However, it has been believed to be multifactorial, involving endothelial dysfunction, volume overload, and arteriovenous fistula. Management of PH in kidney transplant candidates and ESRD patients is remarkably understudied. Several treatment options are available for the treatment of PH. However, studies conducted on treating PH in ESRD patients are scarce. There is an increased need for studies on ESRD patients with PH.

Keywords

• Pulmonary hypertension
• End-stage renal disease
• Chronic kidney disease
• Kidney transplantation
• Outcome
• Management