Insulin-like growth factor 1 receptor expression in advanced non-small-cell lung cancer and its impact on overall survival

Abstract

The insulin-like growth factor 1 receptor (IGF1R) expression has been addressed as a potential prognostic marker in non-small-cell lung cancer (NSCLC) in various studies; however, the associations between IGF1R expression and prognosis of advanced NSCLC patients is still controversial. The aim of our observational, cohort study was to evaluate the expression of IGF1R in advanced NSCLC and its prognostic role. A subgroup analysis was performed to address the influence of pre-existing type 2 diabetes mellitus (T2DM) status on IGF1R expression and overall survival (OS).

Keywords

• insulin-like growth factor 1 receptor
• type 2 diabetes mellitus
• advanced non-small-cell lung cancer
• overall survival