Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides

Tom Guterman; Micha Kornreich; Avigail Stern; Lihi Adler-Abramovich; Danny Porath; Roy Beck; Linda J. W. Shimon; Ehud Gazit

doi:10.1038/ncomms13482

Nature Communications (Nov 2016)

Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides

Tom Guterman,
Micha Kornreich,
Avigail Stern,
Lihi Adler-Abramovich,
Danny Porath,
Roy Beck,
Linda J. W. Shimon,
Ehud Gazit

Affiliations

Tom Guterman: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University
Micha Kornreich: The Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University
Avigail Stern: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus
Lihi Adler-Abramovich: Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University
Danny Porath: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus
Roy Beck: The Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University
Linda J. W. Shimon: Department of Chemical Research Support, Weizmann Institute of Science
Ehud Gazit: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University

DOI: https://doi.org/10.1038/ncomms13482
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The application of nanofibres formed from monomers of bacterial type IV pili in vitrohas proven to be complex. Here, the authors have overcome this limitation by using a reductionist approach to design a self-assembling pilin-based 20-mer peptide capable of forming a supramolecular beta sheet.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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