Nature Communications (Nov 2022)
Lipidomic signatures align with inflammatory patterns and outcomes in critical illness
- Junru Wu,
- Anthony Cyr,
- Danielle S. Gruen,
- Tyler C. Lovelace,
- Panayiotis V. Benos,
- Jishnu Das,
- Upendra K. Kar,
- Tianmeng Chen,
- Francis X. Guyette,
- Mark H. Yazer,
- Brian J. Daley,
- Richard S. Miller,
- Brian G. Harbrecht,
- Jeffrey A. Claridge,
- Herb A. Phelan,
- Brian S. Zuckerbraun,
- Matthew D. Neal,
- Pär I. Johansson,
- Jakob Stensballe,
- Rami A. Namas,
- Yoram Vodovotz,
- Jason L. Sperry,
- Timothy R. Billiar,
- PAMPer study group
Affiliations
- Junru Wu
- Department of Surgery, University of Pittsburgh
- Anthony Cyr
- Department of Surgery, University of Pittsburgh
- Danielle S. Gruen
- Department of Surgery, University of Pittsburgh
- Tyler C. Lovelace
- Department of Computational and Systems Biology, University of Pittsburgh
- Panayiotis V. Benos
- Department of Computational and Systems Biology, University of Pittsburgh
- Jishnu Das
- Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine
- Upendra K. Kar
- Department of Surgery, University of Pittsburgh
- Tianmeng Chen
- Department of Surgery, University of Pittsburgh
- Francis X. Guyette
- Department of Emergency Medicine, Medicine, University of Pittsburgh
- Mark H. Yazer
- The Institute for Transfusion Medicine
- Brian J. Daley
- Department of Surgery, University of Tennessee Health Science Center
- Richard S. Miller
- Department of Surgery, Vanderbilt University Medical Center
- Brian G. Harbrecht
- Department of Surgery, University of Louisville
- Jeffrey A. Claridge
- Metro Health Medical Center, Case Western Reserve University
- Herb A. Phelan
- Department of Surgery, University of Texas Southwestern
- Brian S. Zuckerbraun
- Department of Surgery, University of Pittsburgh
- Matthew D. Neal
- Department of Surgery, University of Pittsburgh
- Pär I. Johansson
- Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital
- Jakob Stensballe
- Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital
- Rami A. Namas
- Department of Surgery, University of Pittsburgh
- Yoram Vodovotz
- Department of Surgery, University of Pittsburgh
- Jason L. Sperry
- Department of Surgery, University of Pittsburgh
- Timothy R. Billiar
- Department of Surgery, University of Pittsburgh
- PAMPer study group
- DOI
- https://doi.org/10.1038/s41467-022-34420-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Alterations in lipid metabolism and circulating lipid species have been reported in patients with acute critical illness. Here the authors show that selective rise in systemic phosphatidylethanolamine levels is a common feature of critical illness that associates with worse clinical outcomes.
