Nature Communications (Feb 2017)
Connecting genetic risk to disease end points through the human blood plasma proteome
- Karsten Suhre,
- Matthias Arnold,
- Aditya Mukund Bhagwat,
- Richard J. Cotton,
- Rudolf Engelke,
- Johannes Raffler,
- Hina Sarwath,
- Gaurav Thareja,
- Annika Wahl,
- Robert Kirk DeLisle,
- Larry Gold,
- Marija Pezer,
- Gordan Lauc,
- Mohammed A. El-Din Selim,
- Dennis O. Mook-Kanamori,
- Eman K. Al-Dous,
- Yasmin A. Mohamoud,
- Joel Malek,
- Konstantin Strauch,
- Harald Grallert,
- Annette Peters,
- Gabi Kastenmüller,
- Christian Gieger,
- Johannes Graumann
Affiliations
- Karsten Suhre
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City
- Matthias Arnold
- Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Aditya Mukund Bhagwat
- Proteomics Core, Weill Cornell Medicine-Qatar, Education City
- Richard J. Cotton
- Proteomics Core, Weill Cornell Medicine-Qatar, Education City
- Rudolf Engelke
- Proteomics Core, Weill Cornell Medicine-Qatar, Education City
- Johannes Raffler
- Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Hina Sarwath
- Proteomics Core, Weill Cornell Medicine-Qatar, Education City
- Gaurav Thareja
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City
- Annika Wahl
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Robert Kirk DeLisle
- SomaLogic
- Larry Gold
- SomaLogic
- Marija Pezer
- Genos Ltd, Glycoscience Research Laboratory
- Gordan Lauc
- Genos Ltd, Glycoscience Research Laboratory
- Mohammed A. El-Din Selim
- Department of Dermatology, Hamad Medical Corporation
- Dennis O. Mook-Kanamori
- Leiden University Medical Centre
- Eman K. Al-Dous
- Genomics Core, Weill Cornell Medicine-Qatar, Education City
- Yasmin A. Mohamoud
- Genomics Core, Weill Cornell Medicine-Qatar, Education City
- Joel Malek
- Genomics Core, Weill Cornell Medicine-Qatar, Education City
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Harald Grallert
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Annette Peters
- Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
- Gabi Kastenmüller
- Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Johannes Graumann
- Proteomics Core, Weill Cornell Medicine-Qatar, Education City
- DOI
- https://doi.org/10.1038/ncomms14357
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Individual genetic variation can affect the levels of protein in blood, but detailed data sets linking these two types of data are rare. Here, the authors carry out a genome-wide association study of levels of over a thousand different proteins, and describe many new SNP-protein interactions.
