Numerical simulations of a two-strain dengue model to investigate the efficacy of the deployment of Wolbachia-carrying mosquitoes and vaccination for reducing the incidence of dengue infections

Abstract

This study investigated the usefulness of a two-serotype dengue mathematical model to gain insights into the effects of antibody-dependent enhancement and temperature on dengue transmission dynamics in the presence of vaccination and Wolbachia-carrying mosquitoes. In particular, the effects of temperature on the mosquito death and maturation rates in secondary infections were examined. A deterministic mathematical model was formulated and analysed to address this problem. The results suggest that controlling the population of aquatic mosquitoes is appropriate for reducing the incidence of secondary infections. Furthermore, the wAu Wolbachia strain was more effective in reducing secondary infections.

Keywords

• Dengue
• Mathematical model
• Wolbachia
• Vaccination
• Antibody-dependent enhancement