Nature Communications (Jul 2021)
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma
- Chen He,
- Ke Xu,
- Xiaoyan Zhu,
- Paige S. Dunphy,
- Brian Gudenas,
- Wenwei Lin,
- Nathaniel Twarog,
- Laura D. Hover,
- Chang-Hyuk Kwon,
- Lawryn H. Kasper,
- Junyuan Zhang,
- Xiaoyu Li,
- James Dalton,
- Barbara Jonchere,
- Kimberly S. Mercer,
- Duane G. Currier,
- William Caufield,
- Yingzhe Wang,
- Jia Xie,
- Alberto Broniscer,
- Cynthia Wetmore,
- Santhosh A. Upadhyaya,
- Ibrahim Qaddoumi,
- Paul Klimo,
- Frederick Boop,
- Amar Gajjar,
- Jinghui Zhang,
- Brent A. Orr,
- Giles W. Robinson,
- Michelle Monje,
- Burgess B. Freeman III,
- Martine F. Roussel,
- Paul A. Northcott,
- Taosheng Chen,
- Zoran Rankovic,
- Gang Wu,
- Jason Chiang,
- Christopher L. Tinkle,
- Anang A. Shelat,
- Suzanne J. Baker
Affiliations
- Chen He
- Department of Developmental Neurobiology
- Ke Xu
- Center for Applied Bioinformatics
- Xiaoyan Zhu
- Department of Developmental Neurobiology
- Paige S. Dunphy
- Department of Developmental Neurobiology
- Brian Gudenas
- Department of Developmental Neurobiology
- Wenwei Lin
- Department of Chemical Biology and Therapeutics
- Nathaniel Twarog
- Department of Chemical Biology and Therapeutics
- Laura D. Hover
- Department of Developmental Neurobiology
- Chang-Hyuk Kwon
- Department of Developmental Neurobiology
- Lawryn H. Kasper
- Department of Developmental Neurobiology
- Junyuan Zhang
- Department of Developmental Neurobiology
- Xiaoyu Li
- Department of Pathology
- James Dalton
- Department of Pathology
- Barbara Jonchere
- Department of Tumor Cell Biology
- Kimberly S. Mercer
- Department of Tumor Cell Biology
- Duane G. Currier
- Department of Chemical Biology and Therapeutics
- William Caufield
- Preclinical Pharmacokinetics Shared Resource St. Jude Children’s Research Hospital
- Yingzhe Wang
- Preclinical Pharmacokinetics Shared Resource St. Jude Children’s Research Hospital
- Jia Xie
- Department of Chemical Biology and Therapeutics
- Alberto Broniscer
- Division of Hematology-Oncology, Children’s Hospital of Pittsburgh
- Cynthia Wetmore
- Exelixis, Inc.
- Santhosh A. Upadhyaya
- Department of Oncology
- Ibrahim Qaddoumi
- Department of Oncology
- Paul Klimo
- Department of Surgery, St. Jude Children’s Research Hospital
- Frederick Boop
- Department of Surgery, St. Jude Children’s Research Hospital
- Amar Gajjar
- Department of Oncology
- Jinghui Zhang
- Department of Computational Biology
- Brent A. Orr
- Department of Pathology
- Giles W. Robinson
- Department of Oncology
- Michelle Monje
- Department of Neurology, Stanford University
- Burgess B. Freeman III
- Preclinical Pharmacokinetics Shared Resource St. Jude Children’s Research Hospital
- Martine F. Roussel
- Department of Tumor Cell Biology
- Paul A. Northcott
- Department of Developmental Neurobiology
- Taosheng Chen
- Department of Chemical Biology and Therapeutics
- Zoran Rankovic
- Department of Chemical Biology and Therapeutics
- Gang Wu
- Center for Applied Bioinformatics
- Jason Chiang
- Department of Pathology
- Christopher L. Tinkle
- Department of Radiation Oncology, St. Jude Children’s Research Hospital
- Anang A. Shelat
- Department of Chemical Biology and Therapeutics
- Suzanne J. Baker
- Department of Developmental Neurobiology
- DOI
- https://doi.org/10.1038/s41467-021-24168-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Patient-derived xenografts provide a resource for basic and translational cancer research. Here, the authors generate multiple pediatric high-grade glioma xenografts, use omics technologies to show that they are representative of primary tumours and use them to assess therapeutic response.
