Neurobiology of Aggressive Behavior—Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

Henning Vaeroy; Frida Schneider; Sergueï O. Fetissov

doi:10.3389/fpsyt.2019.00872

Frontiers in Psychiatry (Dec 2019)

Neurobiology of Aggressive Behavior—Role of Autoantibodies Reactive With Stress-Related Peptide Hormones

Henning Vaeroy,
Frida Schneider,
Sergueï O. Fetissov

Affiliations

Henning Vaeroy: Department of Psychiatric Research, Akershus University Hospital, Nordbyhagen, Norway
Frida Schneider: Department of Psychiatric Research, Akershus University Hospital, Nordbyhagen, Norway
Sergueï O. Fetissov: Inserm UMR1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, University of Rouen Normandy, Rouen, France

DOI: https://doi.org/10.3389/fpsyt.2019.00872
Journal volume & issue: Vol. 10

Abstract

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Adrenocorticotropic hormone together with arginine vasopressin and oxytocin, the neuropeptides regulating the stress response and the hypothalamic-pituitary-adrenal axis activity, are known to modulate aggressive behavior. The functional role of the adrenocorticotropic hormone immunoglobulin G autoantibodies in peptidergic signaling and motivated behavior, including aggression, has been shown in experimental and in vitro models. This review summarizes some experimental data implicating autoantibodies reactive with stress-related peptides in aggressive behavior.

Published in Frontiers in Psychiatry

ISSN: 1664-0640 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.frontiersin.org/journals/psychiatry

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