Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
María N. Barrachina,
Irene Izquierdo,
Lidia Hermida-Nogueira,
Aurelio M. Sueiro,
Esteban Guitián,
Felipe F. Casanueva,
Richard W. Farndale,
Masaaki Moroi,
Stephanie M. Jung,
María Pardo,
Ángel García
Affiliations
María N. Barrachina
Platelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), Spain
Irene Izquierdo
Platelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), Spain
Lidia Hermida-Nogueira
Platelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), Spain
Aurelio M. Sueiro
Grupo de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago (IDIS)/ Servicio de Endocrinología, Xerencia de Xestión Integrada de Santiago (XXS), Spain
Esteban Guitián
Mass Spectrometry and Proteomic Unit, Rede de Infraestructuras de Apoio á Investigación e ao Desenvolvemento Tecnolóxico, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Felipe F. Casanueva
Instituto de Investigación Sanitaria de Santiago (IDIS), Spain; Grupo de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago (IDIS)/ Servicio de Endocrinología, Xerencia de Xestión Integrada de Santiago (XXS), Spain
Richard W. Farndale
Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United Kingdom
Masaaki Moroi
Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United Kingdom
Stephanie M. Jung
Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United Kingdom
María Pardo
Instituto de Investigación Sanitaria de Santiago (IDIS), Spain; Grupo Obesidómica – Instituto de Investigación Sanitaria de Santiago (IDIS)
Ángel García
Platelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago (IDIS), Spain; Corresponding author. Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Avda de Barcelona s/n, 15782, Santiago de Compostela, Spain.
This data article is associated with the manuscript “GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity” [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.
