The Application of Field-Flow Fractionation to the Analysis of Nanomedicines

Abstract

The combination of field-flow fractionation with powerful leading-edge detectors can be applied to the measurement of nanomaterial physicochemical properties, and the creation of harmonized robust measurement protocols. The Multiscale Metrology Suite (MMS) at the University of Strathclyde is a unique internationally leading facility combining multiple leading-edge field flow fractionation modalities(electric, asymmetric and centrifugal) with in-line Raman, inductively-coupled plasma (ICP) mass spectrometry and multimodal detector capability. Using exemplar case studies, we demonstrate the application of various FFF hyphenations for the analysis of a diverse materials portfolio. One of the goals for the MMS is to raise the standards of traditional academic analytical support underpinning pioneering academic engineering, physical and life sciences research exploring novel materials as diagnostics and therapeutics.

Keywords

• field flow fractionation
• nanomedicine
• analysis
• drug development