Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases
Shaza Issa,
Haidar Fayoud,
Alisa Shaimardanova,
Albert Sufianov,
Galina Sufianova,
Valeriya Solovyeva,
Albert Rizvanov
Affiliations
Shaza Issa
Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia
Haidar Fayoud
Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia
Alisa Shaimardanova
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia
Albert Sufianov
Department of Neurosurgery, Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Russia
Galina Sufianova
Department of Pharmacology, Tyumen State Medical University, 625023 Tyumen, Russia
Valeriya Solovyeva
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia
Albert Rizvanov
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia
Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.
