Nature Communications (Dec 2019)

Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection

  • Mark J. McCarron,
  • Magali Irla,
  • Arnauld Sergé,
  • Saidi M’Homa Soudja,
  • Julien C. Marie

DOI
https://doi.org/10.1038/s41467-019-13456-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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. TGFβ is critical for limiting autoreactive responses of peripheral T cells. Here, the authors show that TGFβ signaling in thymocytes mediates elimination of self-reactive T cells and promotes the expression of self-antigens by medullary thymic epithelial cells.