Nature Communications (Nov 2021)
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
- Matthew C. Pahl,
- Claudia A. Doege,
- Kenyaita M. Hodge,
- Sheridan H. Littleton,
- Michelle E. Leonard,
- Sumei Lu,
- Rick Rausch,
- James A. Pippin,
- Maria Caterina De Rosa,
- Alisha Basak,
- Jonathan P. Bradfield,
- Reza K. Hammond,
- Keith Boehm,
- Robert I. Berkowitz,
- Chiara Lasconi,
- Chun Su,
- Alessandra Chesi,
- Matthew E. Johnson,
- Andrew D. Wells,
- Benjamin F. Voight,
- Rudolph L. Leibel,
- Diana L. Cousminer,
- Struan F. A. Grant
Affiliations
- Matthew C. Pahl
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Claudia A. Doege
- Department of Pathology, Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University Vagelos College of Physicians and Surgeons
- Kenyaita M. Hodge
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Sheridan H. Littleton
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Michelle E. Leonard
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Sumei Lu
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Rick Rausch
- Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, Vagelos College of Physicians and Surgeons
- James A. Pippin
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Maria Caterina De Rosa
- Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, Vagelos College of Physicians and Surgeons
- Alisha Basak
- Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, Vagelos College of Physicians and Surgeons
- Jonathan P. Bradfield
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Reza K. Hammond
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Keith Boehm
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Robert I. Berkowitz
- Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine
- Chiara Lasconi
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Chun Su
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Alessandra Chesi
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Matthew E. Johnson
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Andrew D. Wells
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Benjamin F. Voight
- Department of Genetics, University of Pennsylvania
- Rudolph L. Leibel
- Division of Molecular Genetics (Pediatrics) and the Naomi Berrie Diabetes Center, Columbia University Vagelos College of Physicians and Surgeons
- Diana L. Cousminer
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- Struan F. A. Grant
- Center for Spatial and Functional Genomics, Children’s Hospital of Philadelphia
- DOI
- https://doi.org/10.1038/s41467-021-27001-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron model across three stages of differentiation.
